Ubiquitin-proteasome dependent regulation of Profilin2 (Pfn2) by a cellular inhibitor of apoptotic protein 1 (cIAP1)

Jeong, Dar Heum; Choi, Ye Na; Seo, Tae Woong; Lee, Ji Sun; Yoo, Soon Ji

doi:10.1016/j.bbrc.2018.10.115

Cited by 7 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the Ramachandran diagram, we can see that 99 residues are in the most favored zones, equivalent to 84.6% of the 1D1J, and 18 residues in the allowed zones are equivalent to 15.4% of the 1D1J. Let us always remember that when we calculate the percent, we have to exclude the terminal amino acids (02), glycines (18), and prolines (2).…”

Section: Resultsmentioning

confidence: 99%

Oleanolic Acid as a Possible Inhibitor of Pfn2: In silico Approach

Cárdenas-Pillco

Cabrera-del-Carpio

Quispe

et al. 2022

Preprint

View full text Add to dashboard Cite

Colorectal cancer (CRC) has a high mortality rate and has recently involved human profilin II (Pfn2), an actin-binding protein promoter of its invasiveness and progression. This work evaluated the binding affinity of oleanolic acid (Naturally Occurring Saponin) over Pfn2 and its structural stability. QM and MM techniques were applied to perform geometrical optimization and calculation of the reactive sites from Oleanolic Acid, whereas molecular docking and MD simulations for protein-ligand interaction under physiological conditions. Oleanolic acid saponin showed a high binding affinity to the Pfn2 PLP-binding site. Analysis of the protein-ligand structure suggests saponin as a molecule with high potential for developing new drugs against Pfn2 in colorectal cancer cells.

show abstract

Section: Resultsmentioning

confidence: 99%

Oleanolic Acid as a Possible Inhibitor of Pfn2: In silico Approach

Cárdenas-Pillco

Cabrera-del-Carpio

Quispe

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Profilins are actin-binding proteins that regulate cell structure by controlling signal-dependent actin polymerization ( 39 ). The profilin gene family comprises two major isoforms: PFN1 and PFN2 ( 40 ). Mouse profilin I is ubiquitously expressed in all tissues except skeletal muscle, whereas profilin IIA is mainly expressed in neuronal tissues ( 41 ).…”

Section: Discussionmentioning

confidence: 99%

Profilin 2 isoform expression is associated with lung metastasis of colorectal cancer according to a comprehensive gene expression study using a mouse model

Toyota,

Tsuruta,

Tajima

et al. 2024

Oncol Lett

View full text Add to dashboard Cite

“…PARVA encodes for the α-parvin protein that is involved in the regulation of the actin cytoskeleton dynamism (Sepulveda and Wu, 2006). PFN2 is an actin-binding protein that regulates the architecture of the synapse and the cytoskeleton (Jeong et al, 2018). To each miRNA found in hPDLSC-derived EVs is associated a Target Gene and the kind of cancer in which it is found deregulated inside the Human MicroRNA Disease Database along with the Reference in which it is described.…”

Section: Discussionmentioning

confidence: 99%

Extracellular Vesicles of Human Periodontal Ligament Stem Cells Contain MicroRNAs Associated to Proto-Oncogenes: Implications in Cytokinesis

et al. 2020

View full text Add to dashboard Cite

The human Periodontal Ligament Stem Cells (hPDLSCs) exhibit self-renewal capacity and clonogenicity potential. The Extracellular Vesicles (EVs) secreted by hPDLSCs are particles containing lipids, proteins, mRNAs, and non-coding RNAs, among which microRNAs, that are important in intercellular communication. The purpose of this study was the analysis of the non-coding RNAs contained in the EVs derived from hPDLSCs using Next Generation Sequencing. Moreover, our data were enriched using bioinformatic tools. The analysis highlighted the presence of non-coding RNAs and five microRNAs: MIR24-2, MIR142, MIR335, MIR490, and MIR296. Our results show that these miRNAs target the genes classified in two terms of the Gene Ontology: "Ras protein signal transduction" and "Actin/microtubule cytoskeleton organization." Noteworthy, the in-deep analysis of our EVs highlights that the miRNAs could be implicated in the silencing of proto-oncogenes involved in 12 different types of tumors.

show abstract

Ubiquitin-proteasome dependent regulation of Profilin2 (Pfn2) by a cellular inhibitor of apoptotic protein 1 (cIAP1)

Cited by 7 publications

References 25 publications

Oleanolic Acid as a Possible Inhibitor of Pfn2: In silico Approach

Oleanolic Acid as a Possible Inhibitor of Pfn2: In silico Approach

Profilin 2 isoform expression is associated with lung metastasis of colorectal cancer according to a comprehensive gene expression study using a mouse model

Extracellular Vesicles of Human Periodontal Ligament Stem Cells Contain MicroRNAs Associated to Proto-Oncogenes: Implications in Cytokinesis

Contact Info

Product

Resources

About