Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication
Li Zhou,
Ruochuan Liu,
Heather Pathak
et al.
Abstract:The highly infectious coronavirus SARS-CoV-2 relies on the viral main protease (M pro , also known as 3CLpro or Nsp5) to proteolytically process the polyproteins encoded by the viral genome for the release of functional units in the host cells to initiate viral replication. M pro also interacts with host proteins of the innate immune pathways, such as IRF3 and STAT1, to suppress their activities and facilitate virus survival and proliferation. To identify the host mechanism for regulating M pro , we screened v… Show more
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