Ubiquitin Is Not a Blood Biomarker of an Early Cognitive Decline in the Polish Elderly

Abstract

Together with development of new pharmaceutical interventions, as well as the introduction of the concept of initial dementia phase, the demand for early diagnosis has been growing. Research on potential blood biomarkers, amazingly attractive, mainly due to the facility of deriving the material, has provided ambiguous results throughout. The existence of an association between ubiquitin and Alzheimer’s disease pathology suggests that it could be a potential neurodegeneration biomarker. The present study aims to identify and assess the relationship between ubiquitin with regard to the adequacy as a biomarker of an initial dementia and cognitive decline in the elderly. Method: The study sample was composed of 230 participants: 109 women and 121 men aged 65 and older. The relationships of plasma ubiquitin levels with cognitive performance, gender, and age were analyzed. The assessments were performed in three groups of cognitive functioning level: cognitively normal, mild cognitive impairment, and mild dementia, of which the subjects were divided with the Mini-Mental State Examination (MMSE). Results: No significant disparities in plasma ubiquitin levels for various levels of cognitive functioning were identified. Significantly higher plasma ubiquitin levels in women were found in comparison to men. No significant differences were found in ubiquitin concentrations based on age. Results suggest that ubiquitin does not meet the requirements for qualification as a blood biomarker of an early cognitive decline. In order to thoroughly evaluate the potential of research on ubiquitin in connection to an early neurodegenerative process, further studies are needed.

Almost 50 Years of Monomeric Extracellular Ubiquitin (eUb)

“…Further, we review applications of monomeric Ub as scaffolds to improve the uptake of active peptides into the cell [ 25 ]. Approaches of Ub as a biomarker have been discussed elsewhere [ 26 ] and are beyond the scope of this review.…”

Almost 50 Years of Monomeric Extracellular Ubiquitin (eUb)

“…We also discuss the properties of eUb reported during the reproduction of different species. Further, we review applications of monomeric Ub as scaffolds to improve the uptake of active peptides into the cell [25] Approaches of Ub as a biomarker have been discussed elsewhere [26,27] and are beyond the scope of this review.…”