Ubiquitin in the immune system

Zinngrebe, Julia; Montinaro, Antonella; Peltzer, Nieves; Walczak, Henning

doi:10.1002/embr.201338025

Cited by 187 publications

(179 citation statements)

References 207 publications

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“…75 Ubiquitin is a highly conserved polypeptide with 76 amino acids with the property of reversible posttranslational modification. 76 Ubiquitination of proteins occurs in host cells in order to sort the proteins for degradation as well as for other cellular processes. Usually, the 26S proteasome machinery carries out ubiquitination of proteins.…”

Section: Manipulation Of Host Cellular and Subcellular Targets By E mentioning

confidence: 99%

Effector triggered manipulation of host immune response elicited by different pathotypes ofEscherichia coli

Jayamani

Mylonakis

2014

Virulence

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Effectors are virulence factors that are secreted by bacteria during an infection in order to subvert cellular processes or induce the surveillance system of the host. Pathogenic microorganisms encode effectors, toxins and components of secretion systems that inject the effectors to the host. Escherichia coli is part of the innocuous commensal microbial flora of the gastrointestinal tract. However, pathogenic E. coli can cause diarrheal and extraintestinal diseases. Pathogenic E. coli uses secretion systems to inject an array of effector proteins directly into the host cells. Herein, we discuss the effectors secreted by different pathotypes of E. coli and provide an overview of strategies employed by effectors to target the host cellular and subcellular processes as well as their role in triggering host immune response.

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Section: Manipulation Of Host Cellular and Subcellular Targets By E mentioning

confidence: 99%

Effector triggered manipulation of host immune response elicited by different pathotypes ofEscherichia coli

Jayamani

Mylonakis

2014

Virulence

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“…Following secretion, these cytokines prime other immune cells to prepare them for defense against microbial infections. Given that the Ub system-mediated regulation of the TLR, RLR and TNF-α signaling pathways has been well documented in several previous reviews, 12,14 we will focus our discussion on NLR signaling.…”

Section: Modulation Of Innate Immune Signaling By the Ubiquitin Systemmentioning

confidence: 99%

The ubiquitin system: a critical regulator of innate immunity and pathogen–host interactions

Chai

Liu

2016

Cell Mol Immunol

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The ubiquitin system comprises enzymes that are responsible for ubiquitination and deubiquitination, as well as ubiquitin receptors that are capable of recognizing and deciphering the ubiquitin code, which act in coordination to regulate almost all host cellular processes, including host-pathogen interactions. In response to pathogen infection, the host innate immune system launches an array of distinct antimicrobial activities encompassing inflammatory signaling, phagosomal maturation, autophagy and apoptosis, all of which are fine-tuned by the ubiquitin system to eradicate the invading pathogens and to reduce concomitant host damage. By contrast, pathogens have evolved a cohort of exquisite strategies to evade host innate immunity by usurping the ubiquitin system for their own benefits. Here, we present recent advances regarding the ubiquitin system-mediated modulation of host-pathogen interplay, with a specific focus on host innate immune defenses and bacterial pathogen immune evasion.

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“…In addition to protein degradation, ubiquitination has also been directly involved in various cellular signaling events, including DNA damage repair [3], immunity [4][5][6], T-lymphocyte control [7], and cell division [8,9]. Recent progress in ubiquitin biology revealed that various forms of unanchored ubiquitin are also involved in cellular signaling [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

An ubiquitin-binding molecule can work as an inhibitor of ubiquitin processing enzymes and ubiquitin receptors

Nguyen

Ghosh

et al. 2016

Biochemical and Biophysical Research Communications

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The ubiquitin pathway plays a critical role in regulating diverse biological processes, and its dysregulation is associated with various diseases. Therefore, it is important to have a tool that can control the ubiquitin pathway in order to improve understanding of this pathway and to develop therapeutics against relevant diseases. We found that Chicago Sky Blue 6B binds directly to the β-groove, a major interacting surface of ubiquitin. Hence, it could successfully inhibit the enzymatic activity of ubiquitin processing enzymes and the binding of ubiquitin to the CXCR4, a cell surface ubiquitin receptor. Furthermore, we demonstrated that this ubiquitin binding chemical could effectively suppress the ubiquitin induced cancer cell migration by blocking ubiquitin-CXCR4 interaction. Current results suggest that ubiquitin binding molecules can be developed as inhibitors of ubiquitin-protein interactions, which will have the value not only in unveiling the biological role of ubiquitin but also in treating related diseases.

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Ubiquitin in the immune system

Cited by 187 publications

References 207 publications

Effector triggered manipulation of host immune response elicited by different pathotypes ofEscherichia coli

Effector triggered manipulation of host immune response elicited by different pathotypes ofEscherichia coli

The ubiquitin system: a critical regulator of innate immunity and pathogen–host interactions

An ubiquitin-binding molecule can work as an inhibitor of ubiquitin processing enzymes and ubiquitin receptors

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