Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice

Abstract

Aim: The present study was conducted to define the relationship between the anti-aging effect of ubiquinol-10 supplementation and mitochondrial activation in senescence-accelerated mouse prone 1 (SAMP1) mice. Results: Here, we report that dietary supplementation with ubiquinol-10 prevents age-related decreases in the expression of sirtuin gene family members, which results in the activation of peroxisome proliferator-activated receptor c coactivator 1a (PGC-1a), a major factor that controls mitochondrial biogenesis and respiration, as well as superoxide dismutase 2 (SOD2) and isocitrate dehydrogenase 2 (IDH2), which are major mitochondrial antioxidant enzymes. Ubiquinol-10 supplementation can also increase mitochondrial complex I activity and decrease levels of oxidative stress markers, including protein carbonyls, apurinic/apyrimidinic sites, malondialdehydes, and increase the reduced glutathione/oxidized glutathione ratio. Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1a by increasing cyclic adenosine monophosphate (cAMP) levels that, in turn, activate cAMP response element-binding protein (CREB) and AMP-activated protein kinase (AMPK). Innovation and Conclusion: These results show that ubiquinol-10 may enhance mitochondrial activity by increasing levels of SIRT1, PGC-1a, and SIRT3 that slow the rate of age-related hearing loss and protect against the progression of aging and symptoms of age-related diseases.

PGC-1α, glucose metabolism and type 2 diabetes mellitus

“…Further study has illuminated the complex relationship between these transcription factors. Recent research on ubiquinol-10 has indicated that SIRT3 is under the control of cAMP/AMPK/SIRT1/PGC-1α signaling (Tian et al 2014), whereas SIRT5 is reported to increase ATP synthesis and oxygen consumption in HepG2 cells, which is antagonized by PGC-1α and AMPK (Buler et al 2014). Surprisingly, recent study suggests that the deacetylase SIRT6 can suppress hepatic glucose production by acting as a positive regulator of general control non-derepressible 5 (GCN5)-mediated acetylation of PGC-1α (Dominy et al 2012).…”

Coenzyme Q10 Status as a Determinant of Muscular Strength in Two Independent Cohorts

“…Dietary supplementation with CoQ abolished age-related increases of SMPD activity in the rat liver plasma membrane [18]. Moreover, it was shown that a higher expression of muscle peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a major factor that controls mitochondrial biogenesis and respiration, protects from sarcopenia during aging [19] and that PGC-1α expression was increased in SAMP1 mice by dietary supplementation of reduced CoQ 10 (ubiquinol) [20]. …”

Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial

“…One of the mechanisms responsible is an increase in the mass of skeletal muscle through protein synthesis. On the other hand, co-enzyme Q10 [11][12][13][14], L-carnitine [15,16], and polyphenol [17] have been reported as ingredients that effectively improve muscular metabolism and reduce oxidation stress.…”