Über Zusammenhänge zwischen der Senkung des arteriellen und des portalen Blutdrucks und dem Strömungsstillstand in den Lebersinusoiden

Krarup, N. The effect of hemorrhage on hepatosplanchnic hemodynamics, liver function and hepatic metabolism. Acta physiol. scand. 1973. 89. 269–277. Cats in the postabsoiptive state and anesthetized with chloralose were used for the experiments. Following a control period the cats were bled approximately 25 % of the blood volume. The total liver blood flow decreased in parallel to the mean arterial blood pressure, due to a large decrease in portal flow, whereas the hepatic arterial flow remained constant. Thus the splanchnic vascular resistance was not changed, the hepatic arterial resistance decreased, and the gastrointestinal resistance increased after the hemorrhage. Also the portal venous resistance was significantly increased. The hemorrhage resulted in hepatic glycogenolysis and peripheral glycolysis, but neither the splanchnic elimination of ethanol, consumption of oxygen nor hepatic dye elimination was decreased, and the hepatic redox level remained unaltered. The results indicate that although hemorrhage is accompanied by marked changes in hepatosplanchnic hemodynamics the intrahepatic distribution of blood flow is not subject to gross alterations.

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Über Zusammenhänge zwischen der Senkung des arteriellen und des portalen Blutdrucks und dem Strömungsstillstand in den Lebersinusoiden

Cited by 2 publications

References 5 publications

Verhalten der Mikrozirkulation der Leber, des arteriellen und portalen Blutdrucks nach Blutentzug und Volumenersatz

Verhalten der Mikrozirkulation der Leber, des arteriellen und portalen Blutdrucks nach Blutentzug und Volumenersatz

The Effect of Hemorrhage on Hepatosplanchnic Hemodynamics, Liver Function and Hepatic Metabolism

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