Über Retinitis exsudativa (Retinitis haemorrhagica externa)

Coats, George

doi:10.1007/bf01858237

Cited by 76 publications

(11 citation statements)

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“…Subsequent to his first description of massive retinal exudation with or without gross vascular disease in three subgroups of patients in 1908, George Coats redefined his classification in 1912 (Coats 1908; Coats 1912). The three groups were merged into one clinical entity occurring unilaterally in juvenile male patients without systemic disease, characterised by massive retinal exudation with haemorrhage leading to retinal detachment, cataract and glaucoma (Coats 1908; Coats 1912).…”

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confidence: 99%

Classification of the spectrum of Coats’ disease as subtypes of idiopathic retinal telangiectasis with exudation

Cahill

O’Keefe

Acheson

et al. 2001

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: An increasing variety of eponymous terms have been used to describe atypical cases of Coats' disease. A group of typical cases of Coats' disease and other cases of differing severity were classified as one of four subtypes of idiopathic retinal telangiectasis with exudation and compared with regard to clinical outcome. Methods: In a retrospective clinical review patients with typical and atypical Coats' disease were classified as severe, focal, juxtafoveal or associated (with another disease) forms of idiopathic retinal telangiectasis with exudation. Results: 53 eyes in 50 patients were examined of which 62% (nΩ31) were male. 12 eyes were classified as severe (group 1), 22 focal (group 2), 12 juxtafoveal (group 3) and 7 associated (group 4). The mean age at diagnosis was lowest in group 1 eyes (6.8 years). The best visual acuity at presentation was 6/60 in group 1 whereas high proportions of eyes in the other groups had initial visual acuities of 6/24 or better. In group 1 only one eye was treated, the majority of eyes were blind or had been enucleated whereas 34 (79%) of eyes in the other groups were suitable for treatment and 29 eyes (67%) retained pre-treatment visual acuity or better at last follow-up. Conclusions: Idiopathic retinal telangiectasis with exudation is a spectrum of disease, which is synonymous with Coats' disease. In this retrospective study eyes with severe idiopathic retinal telangiectasis with exudation corresponding to typical Coats' disease, have poorer vision at presentation, are less suitable for treatment and have worse outcomes than eyes with other subtypes. The spectrum of disease severity seen in idiopathic retinal telangiectasis with exudation may be due to second somatic mutations in genes with an existing germline mutation (the two hit theory) and a mosaic phenotype.Key words: Coats' disease -idiopathic retinal telangiectasis with exudation -spectrum of severity -retrospective review -two hit theory.

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confidence: 99%

Classification of the spectrum of Coats’ disease as subtypes of idiopathic retinal telangiectasis with exudation

Cahill

O’Keefe

Acheson

et al. 2001

Acta Ophthalmologica Scandinavica

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“…Coats' disease is consid ered a retinal syndrome in which abnormal blood vessels lead to massive exudation in adults and children [6][7][8][9][10][11]. Leber's miliary aneurysms may be an initial stage or a special form of Coats' disease, in which vascular anomalies occur with less exudation at the 1 The authors would like to thank Ms. M. Gere for editing the manuscript.…”

Section: Introductionmentioning

confidence: 99%

“…Coats' disease is defined as exudative retinitis in childhood associated with congen ital retinal telangiectasia [1,2]. Leber's mul tiple miliary' aneurysms with retinal degener ation presents nearly the same vascular con ditions [3][4][5], and whether Leber's and Coats' diseases arc distinct entities has been ques tioned.…”

Section: Introductionmentioning

confidence: 99%

Leber’s Miliary Aneurysms in a 63-Year-Old Woman: Concurrence of Regression and Active Lesions (With 1 color plate)

Hayasaka

Katsube²,

Yamamoto³

et al. 1988

Ophthalmologica

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“…The others were 26- and 37-year-old women and 26- and 32-year-old men. His second report, published in 1912, added two 6-year-old girls, a 12-year-old boy, and a 29-year-old man [4]. Based on these patients and the literature, Coats concluded that exudative retinitis typically affected young people with an average age of 16 years and that it was more frequent in men as compared to women, with a ratio of 26:13 [3,4].…”

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confidence: 99%

“…He was subsequently appointed pathologist and curator at Moorfields in 1905 and assistant ophthalmic surgeon at the Great Northern Central Hospital a year later. Soon thereafter, he completed his clinicopathological treatise, based on 6 patients and a literature review [3], of what he eventually designated exudative retinitis [4] and which soon became widely known as Coats’ disease. Before this, Coats already had published 21 papers on ophthalmic pathology [2].…”

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confidence: 99%

George Coats and His Disease

Kivelä¹

2012

Ophthalmologica

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Über Retinitis exsudativa (Retinitis haemorrhagica externa)

Cited by 76 publications

References 2 publications

Classification of the spectrum of Coats’ disease as subtypes of idiopathic retinal telangiectasis with exudation

Classification of the spectrum of Coats’ disease as subtypes of idiopathic retinal telangiectasis with exudation

Leber’s Miliary Aneurysms in a 63-Year-Old Woman: Concurrence of Regression and Active Lesions (With 1 color plate)

George Coats and His Disease

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