Über Infektionsversuche mit BCG-Keimen bei Groldhamstern

Berger, Karin; Puntigam, F

doi:10.1007/bf02149228

Cited by 2 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some workers consider that under such conditions BCG may be able to muhiply progressively in the organism of the hamster (Hauduroy & Rosset 1951 a, b;Nicod et al 1951;Nicod 1955;Jespersen 1964;Jestersen & Bentzon 1964 a ) . This is contradicted by others, who maintain that hamsters are no more sensitive to BCG than other animals, but that they are sensitive to certain metabolic products or bacterial substances (Berger & Puntigam 1953;van Deinse & Sknkchal 1954;Saenz 1954;van Deinse 1956). In support of their theory, it is emphasized that both heat-killed BCG vaccine and tuberculin can cause fatal disease.…”

Section: Discussionmentioning

confidence: 91%

The Potency of BCG Vaccine Determined by the Tuberculin Shock Method on Hamsters

Jespersen

1973

Acta Pathologica Microbiologica Scandinavica Section B Microbio

View full text Add to dashboard Cite

BCG vaccinated hamsters, in contrast to non-vaccinated, have been shown to be sensitive to tuberculin injected intraperitoneally. An introductory study showed that hamsters vaccinated with a strongly potent BCG strain were killed by tuberculin shock using about the same dose of purified tuberculin as in experiments on guinea pigs. I n the main experiment, hamsters were vaccinated with vaccines prepared from BCG strains of weak, medium or strong potency, and injected with a large dose of tuberculin. I t was demonstrated that the number of animals that died of shock was significantly different in the groups vaccinated with the three vaccines. Thus this method can be used for determination of the potency of a vaccine. The strains examined originated from the Danish strain of BCG received from Paris in 1931.Received 18.xii.72 Accepted 2O.xii.72 Requests for reprints should be addressed to: D r A n d r . Jespersen,

show abstract

Section: Discussionmentioning

confidence: 91%