Über Hydroa aestivale und vacciniforme

Abstract

Aus 4er If. Abteilung flit Geschleohts-un4 Haut1:rankhoiton ties k. k. &ilgemeinon Erankenhauses in "~ien.

Hepatotoxic Drugs Causing Porphyria in Man and Animals*

“…By 1900, Taylor 17 was able to review 34 cases of fatal Sulfonal intoxication, most of which showed significant degrees of "haematoporphyrinuria." These clinical observations led to experimentation with this drug in the rabbit and Stokvis, 8 Kast and Weiss, 18 Nakarei, 19 Neubauer, 20 and Perutz 21 detected "haematoporphyrinuria" within a few days of Sulfonal feeding. At necropsy, only the liver and bile consistently contained high porphyrin concentrations.…”

“…At necropsy, only the liver and bile consistently contained high porphyrin concentrations. 20 On the basis of these findings, Perutz 21 concluded that Sulfonal porphyria represented a form of functional liver disease without histopathologic changes in which the normal breakdown of hemoglobin to bilirubin was derailed, resulting instead in formation of "haematopor phyrin." It is now evident that this latter interpretation was incorrect, in that porphyrins are not derived from breakdown of hemoglobin, but originate in the course of heme synthesis.…”