Über genetische Faktoren bei der Ätiologie von Lippen-Kiefer-Gaumen-Spalten

Schulze, C.

doi:10.1007/bf02163118

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…T he currently favored hypothesis concerning the development of cleft lip and palate (CLP) is based on the assumption that this is etiologically a multifactoriat genetic system with a compound polygeny and threshold value effect [7,17]. In comparison with patients without CLP, CLP patients have a high incidence and prevalence of morphological, numerical and structural anomalies [1,4,5,11,12,14,15,21,23,24], with dental enamel hypoplasia and anomalies of dental form occurring with significant frequency in CLP patients [3,8].…”

Section: Malanczuk T Et Al Changes Of Dental Enamel In Cleft Palatesmentioning

confidence: 99%

“…B ie derzeit am meisten favorisierte Hypothese bei der Entstehung yon Lippen-Kiefer-Gaumensegel-Spalten (LKG-Spalten) geht davon aus, dab es sich dabei ~itiologisch um ein multifaktorielles genetisches System mit additiver Polygenie und Schwellenwerteffekt handelt [7,17]. B ie derzeit am meisten favorisierte Hypothese bei der Entstehung yon Lippen-Kiefer-Gaumensegel-Spalten (LKG-Spalten) geht davon aus, dab es sich dabei ~itiologisch um ein multifaktorielles genetisches System mit additiver Polygenie und Schwellenwerteffekt handelt [7,17].…”

Section: Malanczuk T Et Al Changes Of Dental Enamel In Cleft Palatesunclassified

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Structural changes of dental enamel in both dentitions of cleft lip and palate patients

Malanczuk

Opitz

Retzlaff

1999

J Orofac Orthop/Fortschr Kieferorthop

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The aim of this study was to register the incidence, the location and the character of structural changes in dental morphology in cleft lip and palate patients and to examine the connection between defects of dental enamel and the development of clefts. Twenty-two children and adolescents from a cross-section study carried out in 1987/89 with cleft lip and palate patients could be covered in a second study (longitudinal study). The frequency, the extent and the location of changes of dental hard tissues in both dentitions were assessed in the form of a static and a dynamic examination. Dental enamel anomalies were found in all patients, with opacities of cleft-adjacent incisors being the dominating form of classified defects in both dentitions. In 20 of the 22 examined patients, dental enamel dysplasia was found both in the primary and in the secondary dentition. The intraindividual comparison of the maxillary teeth in both dentitions showed that 19 patients had at least 1 permanent tooth retaining the structural changes in the dental enamel. The location of the defect and the fact that both dentitions were involved reflect the moment of effectiveness of pathogenetic stimuli. Consequently this can be interpreted as the outcome of corresponding pathomechanisms both for disorders of the dental structure and for the development of the primary palate.

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Section: Malanczuk T Et Al Changes Of Dental Enamel In Cleft Palatesmentioning

confidence: 99%

Section: Malanczuk T Et Al Changes Of Dental Enamel In Cleft Palatesunclassified

Structural changes of dental enamel in both dentitions of cleft lip and palate patients

Malanczuk

Opitz

Retzlaff

1999

J Orofac Orthop/Fortschr Kieferorthop

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New findings explaining the mode of action in prevention of facial clefting and first clinical experience

Schubert

Schmidt

Raupach

1990

Journal of Cranio-Maxillofacial Surgery

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Clefts of the Lip and Palate in Twins: Use of DNA Fingerprinting for Zygosity Determination

Eufinger

Rand

Scholz

et al. 1993

The Cleft Palate-Craniofacial Journal

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The study of twins is a well-established method for evaluating the relative roles of heredity and environmental factors in the etiology of diseases. Conclusions depend on zygosity determination and on the classification of minor forms of diseases. This paper reports on ten (5 mono- and 5 dizygotic) out of thirteen twin pairs among 1039 patients with cleft lip and palate (n = 677) or cleft palate (n = 362). Zygosity was determined using “DNA fingerprinting” on blood samples In all 10 pairs and on cleft-associated tissue in one pair. Including minor forms of clefting, two of five pairs of monozygotic and two of five pairs of dizygotic twins of the same sex showed concordance. “DNA fingerprinting” should be established as a definitive method for zygosity determination, and the calculation of concordance rates should always include minor forms of diseases.

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Über genetische Faktoren bei der Ätiologie von Lippen-Kiefer-Gaumen-Spalten

Cited by 4 publications

References 6 publications

Structural changes of dental enamel in both dentitions of cleft lip and palate patients

Structural changes of dental enamel in both dentitions of cleft lip and palate patients

New findings explaining the mode of action in prevention of facial clefting and first clinical experience

Clefts of the Lip and Palate in Twins: Use of DNA Fingerprinting for Zygosity Determination

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