Über Friedreichsche Ataxie und Status dysraphicus

Curtius, Friedrich; Störring, F. K.; Schönberg, K.

doi:10.1007/bf02865775

Cited by 23 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, in the non-diabetics the frequency was 11.5 %, which entirely corresponds to the freauencv of hereditv that Sterkv found in his non-diabetic controls [27]. Curtius et al [6], were unable to find any heredity whatsoever to diabetes on the basis of a detailed genealogic analysis of the relatives of two sisters suffering from Friedreich's ataxia and diabetes. I n their opinion, this should speak against the assumption of a temporary coincidence of two different diseases.…”

Section: Resultsmentioning

confidence: 94%

Diabetes Mellitus in Friedreich's Ataxia

Thorén

1962

Acta Paediatrica

View full text Add to dashboard Cite

Summary In a clinical study of Friedreich's ataxia diabetes mellitus was found in nine of 50 typical cases. The mean age of the diabetes onset was 21.9 years and the clinical type was a severe ketosis‐prone diabetes. In 18 non‐diabetics an intravenous glucose tolerance test was performed. One of these cases was disclosed to be a prediabetes. The mean rate of glucose disappearance was normal. Serum lipid analysis showed a slight elevation in non‐diabetics and a higher in diabetics. The frequency of diabetes mellitus, including the prediabetic case, was 20%. Owing to the low age of the cases and as the glucose tolerance test was performed only in about half of the non‐diabetics, this figure was estimated to be lower than the total frequency in Friedreich's ataxia. A brief survey of the literature is given, and the aetiology of diabetes mellitus in Friedreich's ataxia is discussed. The marked frequency of a known heredity to diabetes in the diabetic cases lends support to the hypthesis of a genetic aetiology. The possibility of an interplay between the defective genes of the two diseases is assumed. The pronouncedly vegetative syndrome occurring in Friedreich's ataxia suggests the possibility of a central nervous factor, though this can hardly be a primary cause of the diabetes.

show abstract