Über einige Probleme der Morphologie und Cytologie des Mycobacterium tuberculosis

Kölbel, Hermann

doi:10.1007/978-3-662-30612-3_6

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Mycobacteria show an extraordinary variability in shape, depending on the environmental conditions [4,36]. The still wide-spread opinion that only solid forms are to be considered viable bacteria can no longer be supported [12,14].…”

Section: 4mentioning

confidence: 99%

Combined Therapy in Leprosy

Freerksen¹,

Rosenfeld²,

Bonnici³

et al. 1978

Chemotherapy

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This report is based on data obtained from 64 lepromatous cases. Despite many years of DDS monotherapy, the homogenates from biopsies of these patients revealed 10⁴ or more bacteria. From the beginning of combination therapy with synergisticacting substances (rifampicin + isoprodian (INH + PTH + DDS) the logarithms of the number of bacteria in the homogenates decreased, both during treatment period and during treatment-free observation period (Figs. 3–8). During the whole time biopsies were taken almost monthly. A considerable regression of the bacterial mass or even «negativity» could be observed within a relatively short time. Once started, the process of reduction of bacteria continued also after termination of therapy. To be able to evaluate a medication, therapy-free observation periods (for a minimum of 5 years) are indispensable.

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Section: 4mentioning

confidence: 99%

Combined Therapy in Leprosy

Freerksen¹,

Rosenfeld²,

Bonnici³

et al. 1978

Chemotherapy

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Spore Formation and 'Dimorphism' in the Mycobacteria

Csillag

1961

Journal of General Microbiology

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SUMMARYI n studying 8 strains of Mycobacterium tuberculosis and 7 strains of atypical mycobacteria all 15 were found to produce, in addition to the typical acid-fast cells, non acid-fast ones, which gradually developed intracellular spore-like bodies ; later free-lying spores were seen in the same cultures. This process occurred in heavily inoculated Lowenstein-Jensen medium cultures, which were at least 8 weeks old and were frequently aerated during incubation. With the atypical mycobacteria it occurred more readily in cultures in Kirschner fluid medium than on solid media. When the cultures containing spores were inoculated on nutrient agar plates, endospore-forming, rapidly growing organisms were obtained, which were not acidfast. These organisms when obtained from independent cultures of the same strain appeared to be identical in bacillary and colonial morphology at their first isolation on nutrient agar, but the organisms from different strains showed variation in these characters. Thus mycobacteria appear able to grow in two different forms: ( a ) form 1, which is acid-fast and multiplies by fission only; (b) form 2, which is not acid-fast, produces endospores regularly and can be maintained in pure culture on nutrient agar. A series of phases of development of form 2 cells in the cultures of form 1 organisms in serial smear examination of Lowenstein-Jensen medium cultures is described. It is suggested that mycobacteria might be considered as dimorphic organisms in the same sense as some of the human pathogenic fungi are known to be dimorphic. Evidence is submitted that form 2 organisms are not contaminants.

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Über einige Probleme der Morphologie und Cytologie des Mycobacterium tuberculosis

Cited by 2 publications

References 35 publications

Combined Therapy in Leprosy

Combined Therapy in Leprosy

Spore Formation and 'Dimorphism' in the Mycobacteria

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