Über einen osmoreceptorisch tätigen Mechanismus in der Leber

A Comparison of Natriuresis after Oral and Intravenous Sodium Loading in Sodium-Depleted Rabbits: Evidence for a Gastrointestinal or Portal Monitor of Sodium Intake

“…There is some evidence that the natriuretic response to a saline load is greater when this is given into the portal vein than into a systemic vein both in dogs (Daly, Roe & Horrocks, 1967) and rats (Haberich, Aziz & Nowacki, 1965). This effect can be abolished by vagotomy (Haberich, Dennhardt & Ohm, 1969).…”

Control of Release of Vasopressin by Neuroendocrine Reflexes

“…A projection to the locus coeruleus has been described in the rat (Vigier & Portalier, 1979). The absence of evoked potentials in the SON and PVN after electrical stimulation of 'an osmosensitive region' in the floor of the fourth ventricle in the cat suggests that there is no monosynaptic pathway from the area postrema (Morest & Sutin, 1961 (Haberich, Aziz & Nowacki, 1965;Haberich, 1968) to have discovered hepatic osmoreceptors is still a highly controversial issue. Their argument is based on the different effects on urine flow of distilled water or saline delivered into the portal vein or the inferior vena cava (Aziz, Haberich & Nowacki, 1964) (Aziz, Nowacki & Haberich, 1966).…”

Visceral control of drinking in rats

“…Rogers, Novin, and Butcher (1979) have reported that the central pathway for hepatic sodium-sensitive and osmosensitive cells parallels previously described gustatory afferents within the brain, as described by Norgren and Leonard (1973). Physiological evidence for hepatic osmoreceptors has been provided by Haberich et al (1965), who demonstrated that hepatic-portal infusion of water resulted in a greater diuretic response than did a comparable infusion into the vena cava of rats. Subsequently, it was reported that when water was infused into the hepatic-portal vein and, simultaneously, 1.8OJo NaCI (twice the isotonic concentration) of equal volume and rate was infused into the vena cava, pronounced diuresis resulted, whereas interchanging the infusion sites yielded transient antidiuresis (Haberich, Aziz, Nowacki, & Ohm, 1969).…”

“…Electrophysiological investigations have provided evidence for the existence of osmo-or sodium-sensitive cells in several species (Adachi, Niijima, & Jacobs, 1976;Andrews & Orbach, 1974;Niijima, 1969). In addition, a number of studies have demonstrated the greater efficacy of hepatic-portal infusions of saline loads than of systemic infusions in eliciting physiologicalcompensatoryresponses (Daly, Roe, & Horrocks, 1967;Haberich, Aziz, & Nowacki, 1965;Lydtin, 1969;Passo, Thornborough, & Rothballer, 1973). However, relatively few investigations have considered the behavioral consequences of the activation of hepatic sodium-or osmo-sensitive mechanisms.…”