1943
DOI: 10.1007/bf01778074
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Über die Zentral Erregende Wirkung des Nicotins

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Cited by 16 publications
(4 citation statements)
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“…Tolerance to a depressant action has also been seen in rats lever-pressing for water reward (Domino and Lutz 1973). In the present study, tolerance did not develop to the stimulant action of nicotine, and parallel findings have been obtained from investigations of locomotor activity (Kuschinksy and Hotovy 1943;Morrison and Stephenson 1972;Clarke and Kumar 1982).…”
Section: Discussionsupporting
confidence: 87%
“…Tolerance to a depressant action has also been seen in rats lever-pressing for water reward (Domino and Lutz 1973). In the present study, tolerance did not develop to the stimulant action of nicotine, and parallel findings have been obtained from investigations of locomotor activity (Kuschinksy and Hotovy 1943;Morrison and Stephenson 1972;Clarke and Kumar 1982).…”
Section: Discussionsupporting
confidence: 87%
“…Rosecrans, 1972), even when residual tolerance to the locomotor depressant action was found (CorfieldSummer & Stolerman, 1978). Equally, tolerance to the locomotor stimulant action of nicotine has not been found (Kuschinsky & Hotovy, 1943;Morrison & Stephenson, 1972;Battig et al, 1976), although this action should also be attenuated by any metabolic tolerance. Some authors have speculated that tolerance to the behavioural depression may be learnt (Stitzer et al, 1970;Domino & Lutz, 1973;Corfield-Sumner & Stolerman, 1978).…”
Section: Discussionmentioning
confidence: 99%
“…Preliminary studies of the time-course of the effects of nicotine (Kuschinsky & Hotovy, 1943;Rosecrans, 1969) suggest that in non-tolerant rats, nicotine may stimulate activity after an initial period of depression. This is consistent with the results of tests of brief duration carried out at different times after injection (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…Nicotine, at low doses, increases overall activity in rats. At higher doses, nicotine initially depresses and then activates ongoing behavior (e.g., Kuschinsky and Hotovy, 1943;Rosecrans, 1969;Morrison and Stephenson, 1972;Stolerman et al, 1973;Battig et al, 1976;Schlatter and Battig, 1979;Michael, 1986, 1992;Jerome and Sandberg, 1987;Clarke et al, 1988;Hakan, 1988;Fung, 1990;Museo and Wise, 1990;Reavill and Stolerman, 1990;Coen, 1991, 1994;O'Neill et al, 1991;Helton et al, 1993;Brioni et al, 1994;Shoaib et al, 1994;Reid et al, 1998;Nadal and Samson, 1999). Tolerance of the depressant effect occurs and, subsequently, the stimulant action of nicotine becomes more pronounced with repeated administration (e.g., Clarke and Kumar, 1983a, b;Weltzl et al, 1988).…”
Section: Nicotine Produces General Activation and Stimulates Ongoing mentioning
confidence: 99%