Über die thromboseverhütende Wirkung des Neodyms (Neodympräparat “Auer 144”)

Failure of Kupffer cell blockade to prevent disseminated intravascular coagulation in endotoxemic rats despite improved survival

“…First described in the early 1930s [12], in 1937 Vincke and Oelkers reported another until then rather unknown property of rare earth metals, the anticoagulant potential, without being able to further clarify their mode of action [33]. At that time different rare earths were even proposed for use as therapeutic anticoagulation agents [7,33], which was later revised as inexpedient because of unwelcome side effects [1]. GdCl 3 is suggested to exert its anticoagulatory action by interfering in the generation of thrombin from prothrombin by factor Xa and by disturbing the proteolytic activation of factor XIII [11].…”

The Anticoagulant Effects in Rabbits and Man of the Intravenous Injection of Salts of the Rare Earths

“…When the dose is increased above 14 mgm., the blood is rendered showed that in our experiments it is not excreted by the human kidney. Available evidence suggests that it is removed by the reticulo-endothelial system of the liver and spleen (6).…”

“…Two patients were given daily doses increasing from 1 to 6 mgm., over a period of a week in an attempt to obviate toxic effects, as suggested by Dyckerhoff and Goossens (6). There were no untoward symptoms, but hemoglobinemia resulted.…”

“…The anticoagulant action persisted for as long as 6 hours after a single injection, and no ill effects were noted. No anticoagulant effects resulted from the oral or subcutaneous administration of neodymium.…”

“…doses intravenously into human subjects, as therapeutic agents in tuberculosis. More recently, Dyckerhoff and Goossens (6) found that neodymium salts injected intravenously prolonged (considerably) the coagulation time of the blood of dogs and man. These authors gave some 30 injections to human subjects, the total dosage of neodymium salt varying from 250 to 500 mgm.…”