Über die Spezifität der Cholin‐esterase‐Hemmung durch Tri‐o‐kresyl‐phosphat

The action of alkyl fluorophosphonates on esterases and other enzymes

“…They poison a range of esterases, some of which have no activity at all towards acetylcholine. In this they resemble tri-o-cresyl phosphate and trio-chlorophenyl phosphate, which have been shown to inhibit serum and tissue cholinesterase, serum lipase, and human milk lipase, but not pancreatic lipase Hottinger & Bloch, 1943). Bloch has drawn attention to the fact that the enzymes which are inhibited by cresyl phosphate are also sensitive to eserine.…”

“…Milk lipase. Human milk contains a powerful lipase, which can easily be estimated by a continuous titration method (Hottinger & Bloch, 1943).…”

Studies on the Industrial Hygiene and Toxicology of Triphenyl Phosphate

“…Hottinger and Bloch showed that TOTP is a cholinesterase inhibitor. 9 Because two other anticholinesterase compounds are said to cause paralysis and demyelination (N-N'-diisopropylphosphorodiamidic fluoride and diisopropyl fluorophosphate), 10,11 there has been considerable interest in the possibility that cholinesterase inhibition is intimately connected with the mechanism of demyelination. It is surprising that TPP, since it resembles TOTP in structure and in its effect in cats, and since it inhibits cholinesterase, has not, except for Hines' study,7 been investigated in this connection.…”