Über die Pharmakokinetik der Cephalosporine im Liquor cerebrospinalis

Dettli, L; Spring, P; Lomar, André Villela

doi:10.1007/bf01781042

Cited by 10 publications

(2 citation statements)

References 3 publications

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“…Our previous in vestigations showed that cefazolin does not penetrate into the CSF sufficiently despite high serum levels [6]. Cephacetrile is re ported to reach higher CSF concentrations [4], Our results confirmed the lack of pene tration of cephacetrile into the CSF in pa tients without meningitis [7],…”

Section: Discussionsupporting

confidence: 79%

Investigations of Cefuroxime Levels in the Cerebrospinal Fluid of Patients with and without Meningitis

et al. 1980

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Cefuroxime was given to 5 neurosurgical patients intravenously in intervals of 8 h. Serum and cerebrospinal fluid (CSF) concentrations were determined periodically over several days. Our results (72 CSF and serum concentrations) show that cefuroxime penetrates the blood CSF barrier to the same low degree as the previously used cephalosporins. In patients with noninflamed meninges the maximum CSF concentration amounted to 0.09 μg/ml, in patients with meningitis the maximum concentration amounted to 8.28 μg/ml. Although these concentrations were achieved, we would recommend cefuroxime only then, if pathogens isolated from CSF are resistant to chloramphenicol and ampicillin or if patients have a penicillin allergy. Cefuroxime is not a suitable drug for perioperative chemoprophylaxis in neurosurgery as used for certain operations.

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Section: Discussionsupporting

confidence: 79%

Investigations of Cefuroxime Levels in the Cerebrospinal Fluid of Patients with and without Meningitis

et al. 1980

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“…FRIEDRICH et al (1979) reported that 2-to 4-g doses of cephracetrile sodium given every 6 h led to no detectable antimicrobial activity in CSF even after 5 days of therapy, suggesting that penetration may result only when there is inflammation or other impairement of the blood--cerebrospinal fluid barrier as observed by DUVAL et al (1974). This may have been alluded to in a study by DETTLI et al (1976), who reported that 3 g cephacetrile injected intravenously every 6 h to patients with bacterial meningitis led to significant CSF levels of antimicrobial activity. WINDORFER and GASTEIGER (1977) found that the disappearance of antimicrobial activity from the serum of premature and full-term babies was 3-5 times slower than from adult serum.…”

Section: Cephacetrilementioning

confidence: 83%