Über die pharmakodynamischen Eigenschaften des N-Dimethylhexahydroisonikotinsäuremethylesterjodids.

Molecular Rearrangements. V. 4-Hydroxy-1-methylisonipecotonitrile as an Intermediate in the Synthesis of Substituted Piperidines1

“…In this alternate method isonicotinic acid wras converted to methyl 1-methylisonipecotate (IX) by the method of Supniewski and Serafinowna. 7 The reaction of IX with phenyllithium gave l-methyl-4-piperidyldi- phenylcarbinol (X), previously reported as the product of a related reaction.8 From several preparations of X a second product, an ether insoluble solid, XI, was obtained.…”