Über die Pathogenese des urtikariell-entzündlichen Juckens

Rajka, E.; Korossy, A.; Gózony, Marianne

doi:10.1159/000256783

Cited by 9 publications

(3 citation statements)

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“…i.e. adrenaline seemed to have a depressive effect on itch (and an enhancing effect on flare) responses, in agreement with other experimental findings (17)(18)(19).…”

Section: Discussionsupporting

confidence: 92%

Pruritus during standardized mental stress. Relationship to psychoneuroendocrine and metabolic parameters

Fjellner,

Arnetz,

Eneroth

et al. 1985

Acta Derm Venereol

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The influence of experimentally-induced emotional stress on pruritic response of human skin was studied in healthy subjects. Experimental activation of the psychoneuroendocrine system was produced by standardized stressors, i.e. a colour-word-conflict test (Stroop-test) and a subsequent mental arithmetic problem. Pruritus was elicited by intradermal injection of histamine. Results obtained were compared with reported feelings of stress, and stress-induced physiological and biochemical changes. Reported stress levels were evaluated by a visual analogue scale. The physiological and biochemical observations included pulse rate, blood pressure, endocrine and metabolic parameters. The experimental model produced adequate psychoneuroendocrine stress reactions. Cutaneous responses to histamine remained despite this unaltered. The cutaneous responses were unrelated to reported stress levels as well as to physiological and biochemical variables prior to stressor exposure. The individual cutaneous reactions to stressor exposure were related to the adrenaline response pattern. Degree of control, ability to predict, and time limitation of the experimental situation may be important factors influencing the experimental outcome.

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“…i.e. adrenaline seemed to have a depressive effect on itch (and an enhancing effect on flare) responses, in agreement with other experimental findings (17)(18)(19).…”

Section: Discussionsupporting

confidence: 92%

Pruritus during standardized mental stress. Relationship to psychoneuroendocrine and metabolic parameters

Fjellner,

Arnetz,

Eneroth

et al. 1985

Acta Derm Venereol

View full text Add to dashboard Cite

show abstract

“…

Seit m e h r als 10 J a h r e n befassen w ir uns m it th eo retisch en und p ra k tisc h e n F rag en des Ju c k e n s. U b e r unsere R e su lta te b e ric h te te n w ir b ish e r in 4 M itteilu n g en [1,2,3,4]. 2.

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“…W ir trach teten , auf diese Weise die W irkung von antiphlogistischen, antihistam inartigen und das vegetative und sensible, eventuell Zentralnervensystem be einflussenden A rzneim itteln in lokaler Anwendung zu prüfen und das prozentuelle W irkungsverhältnis der juekstillenden Arzneien zu bestimmen. W ir fanden schon im Laufe unserer früheren U ntersuchungen [2], daß diejenigen Arzneien, die Vaso konstriktion und G efäßperm eabilitätsverm inderung verursachen, dem nach entzün-dungs-und histam inw idrig wirken oder die Nervenbahn unterbrechen, gleicher maßen auch das durch experim entelle i.k.-M o-Injektion ausgelöste urtikariell-entzündliche Jucken hemmen. Bei der U ntersuchung der q u an titativ geprüften 78 Mit tel stellte sich dann heraus [4], daß 44 im stande waren, in der H älfte bzw.…”

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