Über die Monilethrix

Salamon, T; Schnyder, U. W.

doi:10.1007/bf00486721

Cited by 23 publications

(10 citation statements)

References 15 publications

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“…Other groups have reported on the spontaneous improvement of symptoms in monilethrix during pregnancy [3][4][5]. We our selves observed improvement of the hair anomaly of moni lethrix in a pregnant woman [6], In another girl, coming from a different family, improvement was observed after menarche. Tomkinson [7] noted that keratosis pilaris can disappear in patients with monilethrix when they grow older.…”

Section: Monilethrixsupporting

confidence: 53%

Regression and Disappearance of Clinical Symptoms in Some Cases of Genodermatoses

Salamon

1993

Dermatology

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Genetic skin diseases are usually thought of as stable phenotypes caused by a mutant gene. However, a review of the literature on genodermatoses and my personal experience with a number of these disorders show that the concept of a stable phenotype is not always true. A number of genodermatoses actually show a regression of symptoms. Among these are monilethrix, several types of erythrokeratoderma, several forms of palmoplantar keratoderma such as the varians Wachters type and the Richner-Hanhart syndrome, and some forms of epidermolysis bullosa, for example the Dowling-Meara type. Three different reasons possibly underlying the regression of symptoms in genetic diseases are briefly discussed: (1) environmental factors, (2) hormonal influences and (3) movable, transposable elements causing instability of the genome.

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Section: Monilethrixsupporting

confidence: 53%

Regression and Disappearance of Clinical Symptoms in Some Cases of Genodermatoses

Salamon

1993

Dermatology

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“…Sinee Smith (1) described this eondition as "a rare nodose condition of the hair," several large pedigrees affected by monilethrix have been reported (2)(3)(4)(5)(6)(7)(8) and an autosomal dominant inheritance was suggested (9,10). Sinee Smith (1) described this eondition as "a rare nodose condition of the hair," several large pedigrees affected by monilethrix have been reported (2)(3)(4)(5)(6)(7)(8) and an autosomal dominant inheritance was suggested (9,10).…”

mentioning

confidence: 99%

Monilethrix: an ultrastructural study

1984

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Characteristic moniliform hairs of monilethrix were ultrastructurally examined. By scanning electron microscope, nodes and internodes were seen alternating on the affected hair; the nodes were normal in appearance and thickness, while the internodes were thin and showed ridges and flutes. By transmission electron microscope, the cross sections of the internodes revealed wrinkling of the hair cuticular cells and a reduced number of the cortical cells. Cross sections of the cortical cells per se showed a similar size and a normal keratin pattern in both nodes and internodes, compared with those of control hairs from normal individuals. From these findings, the internodes seemed to be the pathological portions of the moniliform hair, and such abnormal thinning of hair shaft might be caused by a periodical dysfunction of the hair matrix, especially in the hair cortex.

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“…Various authors [1,5] have reported hair involvement of other areas besides the scalp; in our case, the eyebrows were affected in addition to the scalp. Salamon and Schnyder [6] described nail and tooth abnormality while no such association was observed by us and Solomon and G reen [1] in their large series. Keratosis pilaris, a commonly reported accompaniment [1] was present in our case too.…”

Section: Discussionmentioning

confidence: 89%