Über die Entstehung eines Epithelioms beim Menschen nach Experimentellen Arbeiten mit Benzpyren

Klar, E.

doi:10.1007/bf01775127

Cited by 9 publications

(1 citation statement)

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“…LeRoy (77) on the other hand, reported no tumors in rabbits injected with colloidal solutions of 3,4-benzopyrene. Klar (67) cited the case of a man developing epithelioma three months after working with benzopyrene. Taschner (137) produced leucopenia in mice with benzopyrene.…”

Section: Carcinogenic Hydrocarbonsmentioning

confidence: 99%

Recently discovered carcinogenic and anti-cancer agents

Sampey¹

1939

J. Chem. Educ.

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THEfirst experimentally produced cancer in 1915 by the long-continued application of a coal-tar distillate to the ear skin of rabbits (149) confirmed the suspicion that cancer among workmen engaged in coal-tar distillation was an occupational disease. The search for the carcinogenic agent or agents in coal tar has been extended until today scores of substances, many of them far removed chemically from coal tar, are known to produce malignant tumors in laboratory animals. Early in the prosecution of this research the discovery was made that certain agents would prevent the formation of experimental cancer, while others would retard the growth of tumors already present, or bring about their disappearance. A number of reviews of early work on carcinogenic and anti-cancer agents have appeared from time to time. The following bibliography is so arranged as to bring out the major lines the investigations are following at present. r.CARCINOGENIC AGENTS IN TARS Brownlie (20) has recently presented a mass of data in support of the theory that poisonous organic products of high-boiling benzenoid hydrocarbons cause cancer.

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Section: Carcinogenic Hydrocarbonsmentioning

confidence: 99%