Über die Einwirkung von Chlor auf methylierte und acetylierte Harnsäuren

2,4-Oxazolidinediones

“…Caffolide is the spiro compound composed of a hydantoin and a 2,4-oxazolidinedione ring system; all the mono-, di-, and tri-iV-methyl derivatives (62) and a number of A-ethyl-and A-acetyl derivatives are known (63). The compounds, which are obtained from uric acid and its derivatives, have been reviewed The silver salt of 5,5-dimethyl-2,4-oxazolidinedione yields 4-ethoxy-2-oxazclone when treated with ethyl iodide in ether at room temperature (84, 109); methyl iodide and benzyl bromide yield the corresponding enol ethers (84).…”

Structure‐activity relationships of alloxan‐like compounds derived from uric acid

“…The structures shown represent: (A) 5-substituted-isouric acids, (B) 4,5-disubstituted-4,5-dihydrouric acids, (C) 5-substituted-pseudouric acids, (D) dehydrouramil hydrate salts, (E) dehydro-isouramil hydrate salts, (F) alloxan derivatives. The drugs were synthesized according to the following references: 1, Biltz & Pardon (1934); 2, Biltz & Strufe (1916);3, Biltz & Damm (1914);4, Biltz (1910);5, Poje & Rocic (1979);6, Biltz & Heyn (1916);7, Poje et al (1982);8, unpublished;9, Poje et al (1983);10, Rocic et al (1985); 11, Bruckman & Wertheimer (1945, 1947; 12, Regitz & Adolph (1969). They were administered to 620 fasted rats as freshly prepared 2% (w/v) solutions in saline intravenously via a tail vein (except where indicated 'i.p.'…”