Über die Einwirkung des Vitamin C auf das Pathologisch Veränderte Weisse Blutbild

Eufinger, H.; Gaehtgens, G.

doi:10.1007/bf01779758

Cited by 20 publications

(3 citation statements)

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“…Eufinger and Gaehtgens 17 , in 1936, reported the successful treatment of myeloid leukemia using vitamin C, and ever since, it is has been receiving attention as substance capable of acting in carcinogenesis prevention. Several epidemiological studies had been performed trying to relate cancer and vitamin C consumption, in the normal diets or as alimentary supplement.…”

Section: Discussionmentioning

confidence: 99%

“…Diethylnitrosamine (NDEA), a substance known for more than 30 years due to its capacity of formation of tumors, was used in this study for induction of esophageal cancer 18 , following the Rubio standardization 19 and Sallet et al researches 5,6 . The main mechanism by which the vitamin C may interfere with carcinogenesis is related to its ability in reducing the nitrous acid, preventing the formation of nitrosamines in the stomach 17 .…”

Section: Discussionmentioning

confidence: 99%

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Role of the vitamin C in diethylnitrosamine-induced esophageal cancer in Wistar rats

et al. 2009

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Purpose:To evaluate the inhibitory effect of vitamin C on the experimental esophageal carcinogenesis induced by diethylnitrosamine (NDEA). Methods: Sixty Wistar male rats aged three months, with mean weight of 210 g were employed in the study and were divided into four different groups according to the drinking drugs: group I -controls: only water, seven days a week; group II -only vitamin C, seven days a week; group III -NDEA, three days a week and water during the other four days; group IV -NDEA, three days a week and vitamin C during the other four days; group V -NDEA together with vitamin C three days a week, and only water during the other four days and group VI -NDEA together with vitamin C three days a week and vitamin C during the other four days. The dosages of NDEA were: -10 mg. / Kg / day and vitamin C -200 mg / animal / day, dissolved in drinking water. The animals were observed during 180 days and after that each one was sacrificed and its esophagus and the stomach were removed together and macro and microscopically analyzed to identify any tumors. Results: The largest number of tumors was observed in the group III: 48 macroscopic lesions (4.8 lesions per animal) and 23 microscopic lesions (2.3 lesions per animal). The groups that received vitamin C (groups IV, V and VI) showed smaller number of tumors: group V -0.5 macroscopic lesions and 0.3 microscopic lesions per animal and group VI -0.1 macroscopic lesions and 0.1 microscopic lesions per animal. The incidence of tumors in the groups V and VI showed statistical significance (p<0.05), when compared to the other groups. Conclusion: The vitamin C administered together with diethylnitrosamine showed an inhibitory effect on the experimental esophageal carcinogenesis in Wistar rats. Key words: Esophageal Neoplasms. Diethylnitrosamine. Ascorbic Acid. Rats. RESUMO Objetivo: Avaliar o efeito inibidor da vitamina C na carcinogênese esofágica experimental induzida pela dietilnitrosamina (DEN).Métodos: Sessenta ratos Wistar, com idade de três meses, machos, com peso médio de 210 g foram utilizados no estudo e divididos em quatro grupos diferentes, conforme ingestão das drogas: grupo I -controles: ingerindo água sete dias por semana; grupo II -só vitamina C, sete dias por semana; grupo III -DEN, três dias por semana e água durante os outros quatro dias; grupo IV -DEN, três dias por semana e vitamina C durante os outros quatro dias; grupo V -DEN junto com vitamina C três dias por semana, e água os outros quatro dias e grupo VI -DEN junto com vitamina C três dias por semana e só vitamina C durante os outros quatro dias. As dosagens de DEN empregadas foram -10 mg. / Kg / dia e de vitamina C -200 mg / animal / dia, dissolvidos na água de beber. Os animais foram observados durante 180 dias e depois disso sacrificados, tiveram o seu esôfago e o estômago retirados, e macro e microscòpicamente analisados para identificar qualquer tumor. Resultados: O número maior de tumores foi observado no grupo III: 48 lesões macroscópicas (4.8 lesões por animal) e 23 les...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Role of the vitamin C in diethylnitrosamine-induced esophageal cancer in Wistar rats

et al. 2009

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“…However, for those interested in designing such a trial, an encouraging background of publications exists, ranging from individual case reports, through anecdotal accounts, to pilot studies involving large numbers of advanced cancer patients (64,68,100,114,129,146,159,164,177,184,214,248,261,283,287,288,289,320,327,330,331,332), all reporting some degree of clinical benefit conferred by supplemental ascorbate. Our own clinical studies, discussed in several publications (51-53, 56-59, 226), strongly indicate that supplemental ascorbate not only increases well-being but also produces a statistically significant increase in the survival times of advanced cancer patients.…”

Section: Other Relevant Effects Of Ascorbic Acidmentioning

confidence: 99%