Über die Beziehung zwischen Toxizität und immunisierendem Vermögen von Typhus-Impfstoffen

Determination of Potency of Typhoid Antigens by Means of Hemagglutination Inhibition Test

“…Felix (12) however raised objections against it, by reasoning that mucin changes the natural defensive capacity of mice. Löffler (14) did not see any difference of the principle between mucin and saline technique, and in his opinion the "mucin capsule" keeps the de fensive substances of the organism away for a certain period. During this time the germs multiply undisturbed and this mass of microorganisms kills the mice due to their toxicity in a similar way, as with infection without mucin.…”