Über die Behandlung rheumatischer Erkrankungen mit einer Kupfer-Natrium-Salizylat-Komplexverbindung (Permalon)

Hangarter, W.; Lübke, Albert

doi:10.1055/s-0028-1117098

Cited by 14 publications

(3 citation statements)

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“…These positive results with copper complexes were supported by the studies of other workers. 21,22 Hangarter and Lubke 22 treated more than 600 patients suffering from RA with copper salicylate and reported that 65% became symptom free, 23% improved and 12% of the patients remained unchanged. No serious toxic disturbances were recorded in association with the treatment.…”

Section: Coppermentioning

confidence: 99%

Rheumatoid arthritis and metal compounds—perspectives on the role of oxygen radical detoxification†

Aaseth¹,

Haugen²,

Førre³

1998

Analyst

124

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Rheumatoid arthritis (RA) is characterised by migration of activated phagocytes and other leukocytes into synovial and periarticular tissue. Activated oxygen species and other mediating substances from triggered phagocytes appear to exacerbate and perpetuate the rheumatoid condition. Iron excesses are capable of aggravating the arthritic inflammation, probably through their pro-oxidant potentials. In contrast, therapeutically given gold salts, through a lysosomal loading of the metal, inhibit the triggered cells, thereby reducing the toxic oxygen production. Pharmacological doses of zinc also may immobilise macrophages. Furthermore, the copper-zinc-containing enzyme SOD (superoxide dismutase) can act as a scavenger of toxic oxygen in the tissues. Therapeutic remission of RA has been obtained following intraarticular administration of SOD. Intramuscular administration of copper complexes has induced remission in about 60% of RA patients in open studies. Another drug, penicillamine, that protects cellular membranes against toxic oxygen in vitro, is presumed to act as an antirheumatic via the SOD mimetic activity of its copper complex. Thiomalate and other thiols may possess similar activities. Selenium compounds also may act as oxygen radical scavengers. A significant alleviation of articular pain and morning stiffness was obtained following selenium and vitamin E supplementation in a double-blind study on RA patients. The observations reviewed here indicate that metal compounds and other antioxidants can reduce the rheumatic inflammation by reducing the cellular production and/or concentration of toxic oxygen species.

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Section: Coppermentioning

confidence: 99%

Rheumatoid arthritis and metal compounds—perspectives on the role of oxygen radical detoxification†

Aaseth¹,

Haugen²,

Førre³

1998

Analyst

124

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“…An early strategy to circumvent the inherent toxicity of NSAID use was by means of NSAID complexation with metals, particularly Cu. This arose from the research of Hangarter in the mid-twentieth century [ 12 ], and the hypothesis of Sorenson in the 1990s that the in vivo activity of NSAIDs might be due to binding with endogenous Cu [ 13 ], and the gastric-sparing effect of the Cu(II)-NSAID complexes. Many other Cu(II)-NSAID complexes have since been synthesised [ 7 , 13 ] as well as those of other metals, such as Zn(II) [ 14 ], for the assessments of their anti-inflammatory, anti-cancer and anti-diabetic effects.…”

Section: Resultsmentioning

confidence: 99%

A novel class of copper(II)- and zinc(II)-bound non-steroidal anti-inflammatory drugs that inhibits acute inflammation in vivo

et al. 2016

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BackgroundThe ability of Zn(II) and Cu(II) metal complexes of non-steroidal anti-inflammatory drugs (NSAIDs) to inhibit acute arterial inflammation in vivo has been studied. ResultsWhen acute vascular inflammation was induced in normocholesterolemic New Zealand White rabbits by inserting a non-occlusive silastic collar around the common carotid artery, a single oral dose of Cu(II)-indomethacin (Cu(II)Indo, 3 mg/kg) administered by laparotomy achieved a 67 % (8.2 ± 1.7 vs. 2.7 ± 0.4 image units, p < 0.05) reduction in endothelial expression of vascular cell adhesion molecule-1 (VCAM-1) but did not inhibit endothelial intercellular adhesion molecule (ICAM-1) expression significantly. Treatment with Cu(II)-acemetacin (Cu(II)ACM, 3 mg/kg) led to a profound 88 % (8.2 ± 1.7 vs. 1.0 ± 0.5 image units, p < 0.01) reduction in endothelial VCAM-1 expression but did not inhibit ICAM-1 expression, while treatment with Zn(II)-acemetacin (Zn(II)ACM, 3 mg/kg) led to an 84 % (19.3 ± 1.0 vs. 3.1 ± 1.2 image units, p < 0.01) reduction in endothelial ICAM-1 expression and did not inhibit VCAM-1 expression. No adverse gastric, hepatic or renal effects were observed in treated animals. ConclusionThese findings provide the “proof of concept” that this novel class of drug, where there is complexation of NSAIDs with metal ions, has substantial anti-inflammatory effects in an animal model of acute vascular inflammation with the possibility of low rates of adverse effects.

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“…J. G. RADEMACHER[ 9 ] betont in seiner "Erfahrungsheillehre" sogar den besonders gefestigten Gesundheitszustand der Kupferschmiede, an denen die Ärzte verhungern könnten. In neuerer Zeit hat HANGARTER [ 10 ] aus der Beobachtung, daß die Arbeiter eines finnischen Kupferbergwerks auffallend selten an rheumatischen Leiden und Wundinfektionen erkrankten, solange diese Beschäftigung anhielt, eine Kupfer-Behandlung rheumatischer Erkrankungen hergeleitet (Permahn).…”

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Die Krampfbeziehungen von Cuprum

Unseld¹

2007

AHZ

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Über die Behandlung rheumatischer Erkrankungen mit einer Kupfer-Natrium-Salizylat-Komplexverbindung (Permalon)

Cited by 14 publications

References 0 publications

Rheumatoid arthritis and metal compounds—perspectives on the role of oxygen radical detoxification†

Rheumatoid arthritis and metal compounds—perspectives on the role of oxygen radical detoxification†

A novel class of copper(II)- and zinc(II)-bound non-steroidal anti-inflammatory drugs that inhibits acute inflammation in vivo

Die Krampfbeziehungen von Cuprum

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