Über die Ausscheidung von Thymol, Carvacrol, Eugenol und Guajacol und die Verteilung dieser Substanzen im Organismus

Schröder, Victor; Vollmer, Hubert

doi:10.1007/bf01861300

Cited by 23 publications

(4 citation statements)

References 6 publications

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“…This particular enzyme is considered to have protective role against chemical mutagens (Lam and Zheng, 1991). Absorption kinetics and metabolism of the major component of the oil, carvacrol after per os administration in rats, rabbits and dogs has been previously reported (Austgulen et al, 1987;Williams, 1959;Schroder and Vollmer, 1932), while the same parameters have been studied for thymol (Austgulen et al, 1987;Takada et al, 1979;Williams, 1959;Robbins, 1934) showing considerable similarities between them.…”

Section: Safety and Pharmacologymentioning

confidence: 86%

Dittany of Crete: A botanical and ethnopharmacological review

Liolios

Graikou

Skaltsa

et al. 2010

Journal of Ethnopharmacology

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Section: Safety and Pharmacologymentioning

confidence: 86%

Dittany of Crete: A botanical and ethnopharmacological review

Liolios

Graikou

Skaltsa

et al. 2010

Journal of Ethnopharmacology

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“…Instrumental conditions. The GLC system (Hewlett Packard model 5710A) and the GLC-mass spectrometry system (Hewlett Packard model 5992A) were the same as used previously (Skjevrak et al 1986). The capillary GLC columns employed were prepared in our laboratory using SE-54 (bonded phase), OV-1701 (bonded phase), Pluronic 64 and Emulphor.…”

Section: Animal Experimentsmentioning

confidence: 99%

Metabolism in Rats of p‐Cymene Derivatives: Carvacrol and Thymol

Austgulen

Solheim

Scheline

1987

Pharmacology & Toxicology

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The metabolism of carvacrol and thymol in rats was studied using gas chromatographic-mass spectrometric methods. The urinary excretion of metabolites was rapid. Only very small amounts were excreted after 24 hrs. Although large quantities of carvacrol and, especially, thymol were excreted unchanged (or as their glucuronide and sulphate conjugates), extensive oxidation of the methyl and isopropyl groups also occurred. This resulted in the formation of derivatives of benzyl alcohol and 2-phenylpropanol and their corresponding carboxylic acids. In contrast, ring hydroxylation of the two phenols was a minor reaction.

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“…Carvacrol 32 , eugenol 33 , and trans -cinnamaldehyde 34 are all metabolized in the liver and excreted in the kidney within 24 h of administration. Our observation of higher relatively liver and kidney weights from 500 mg/kg EU and 300 mg/kg CAR groups were similar to those reported in both males and female rats 26 when a derivative of cinnamaldehyde, α-amyl cinnamaldehyde, was fed for 14 weeks.…”

Section: Discussionmentioning

confidence: 99%

Effects of intramuscularly injected plant-derived antimicrobials in the mouse model

Johnson

Duan

Srirattana

et al. 2022

Sci Rep

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With increasing antibiotic resistance, the use of plant derived antimicrobials (PDAs) has gained momentum. Here, we investigated the toxicity of trans-cinnamaldehyde, eugenol, and carvacrol after intramuscular injection in mice. Two doses of each PDA—300 and 500 mg/kg body weight—and vehicle controls were injected into the muscle of the right hind limb of CD-1 adult mice (n = 8/treatment). Ten physical/behavioral parameters were monitored hourly for 2 h and twice daily for 4 days post-injection together with postmortem examination of leg muscles and organs. Within the first 2 days of carvacrol treatment, one male died in each dose level and a third male receiving 500 mg/kg was removed from the study. No mortality was seen with any other treatment. Among all 81 parameters examined, significant higher relative liver weights (300 and 500 mg/kg eugenol groups; P < 0.05) and relative kidney weights (300 mg/kg carvacrol group; P < 0.001) were observed. Taken together, little to mild toxicity was seen for trans-cinnamaldehyde and eugenol, respectively, while carvacrol exerted more toxicity in males. This study lays the foundation for future extensive work with large sample size, varied treatment durations, and additional treatment levels.

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Über die Ausscheidung von Thymol, Carvacrol, Eugenol und Guajacol und die Verteilung dieser Substanzen im Organismus

Cited by 23 publications

References 6 publications

Dittany of Crete: A botanical and ethnopharmacological review

Dittany of Crete: A botanical and ethnopharmacological review

Metabolism in Rats of p‐Cymene Derivatives: Carvacrol and Thymol

Effects of intramuscularly injected plant-derived antimicrobials in the mouse model

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