Über den Zustand des Glykogens in der Leber, im Muskel und in Leukocyten. (Zur Kenntnis der Proteinbindung physiologisch wichtiger Stoffe.)

Willstätter, Richard; Rohdewald, Margarete

doi:10.1515/bchm2.1934.225.2-3.103

Cited by 187 publications

(9 citation statements)

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“…drate within a glycogen granule and its association with cellular compartments affect its solubility in acid. As early as 1934, two fractions of glycogen were described according to their solubility in boiling water or cold TCA; the extractable fraction was named lyoglycogen, and the nonextractable fraction was named desmoglycogen (16). Desmoglycogen was reported to include glycogen granules associated with filaments and/or sarcoplasmic reticulum, and lyoglycogen included free unbound granules (17).…”

Section: Glycogen Fractions According To Chemical Propertiesmentioning

confidence: 99%

The dynamic life of the glycogen granule

Prats

Graham

Shearer

2018

Journal of Biological Chemistry

149

133

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Glycogen, the primary storage form of glucose, is a rapid and accessible form of energy that can be supplied to tissues on demand. Each glycogen granule, or "glycosome," is considered an independent metabolic unit composed of a highly branched polysaccharide and various proteins involved in its metabolism. In this Minireview, we review the literature to follow the dynamic life of a glycogen granule in a multicompartmentalized system, the cell, and how and where glycogen granules appear and the factors governing its degradation. A better understanding of the importance of cellular compartmentalization as a regulator of glycogen metabolism is needed to unravel its role in brain energetics.

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Section: Glycogen Fractions According To Chemical Propertiesmentioning

confidence: 99%

The dynamic life of the glycogen granule

Prats

Graham

Shearer

2018

Journal of Biological Chemistry

149

133

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“…Modifications of this procedure, especially those of Somogyi (Somogyi 1934), were used by the Coris and are still the most commonly utilized protocols for glycogen extraction. Another frequently used method, introduced in 1934 (Willstätter and Rohdewald 1934), is extraction with cold trichloroacetic acid (TCA); however, it has been observed that not all glycogen can be extracted by this method (see Section 2.6.2), and a slightly different molecular weight is observed for the purified glycogen (Lazarow 1942;Calder 1991). In 1936, the first reliable procedure for extracting brain glycogen was established utilizing Somogyi's method (Kerr 1938).…”

Section: Emerging Technologies With Staying Power: Periodic Acid-schimentioning

confidence: 99%

“…When the TCA extraction method was first introduced for the purification of glycogen, it was observed that a portion of the glycogen was resistant to extraction by cold TCA (Willstätter and Rohdewald 1934). It could not be released unless the tissue was treated with heat, alkali, or protease, so it was concluded that this resistant fraction was attached to protein, and the two fractions were called lyo-("free") and desmo-("fixed") glycogen (Willstätter and Rohdewald 1934;Van Heijningen and Kemp 1955). Such observations also gave rise to the terms acid-soluble, i.e.…”

Section: Proglycogen and Macroglycogenmentioning

confidence: 99%

Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future

Brewer

Gentry

2019

Advances in Neurobiology

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“…More important was the change in bound and free glycogen. From the work of Willstatter and Rohdewald [49] we know that glycogen exists in tissues in two forms, lyo-glycogen which is easily extractable with trichloracetic acid and boiling water, and desmoglycogen which, combined with proteins, is only to be estimated by the method of potash digestion. As will be seen from the diagram in Fig.…”

Section: Fig83mentioning

confidence: 99%

New Advances in the Chemistry and Biology of Organized Growth

Needham

1936

Proceedings of the Royal Society of Medicine

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This paper comprises the Oliver-Sharpey Lectures for 1936, delivered at the Royal College of Physicians, together with an address to the Section of Pathology of the Royal Society of Medicine, -delivered on the above date.OCT,-PATH. 1Proceedings of the Royal Society of Medicine 3£ an implanted organizer, that is to say, whether, invaginated early, it will come to lie under the presumptive head; or, invaginated late, it will come to lie under the presumptive tail. Spemann [51, specifically investigating this subject, found that head organizer would produce heads either in head or tail regions, while tail orgauizer would produce head in head region and tail in tail region. The organizer itself contains, therefore, some hidden regional quality, determining the regional character of what will be induced, as well as some morphogenetic stimulus which will simply account for the existence of what will be induced. The former type of determination has been called Individuation, and the second type Evocation (Needham, Waddington and Needham [7]) and these terms have become generally adopted. Thus we may say that in an ordinary induction, one of these determinations, evocation, is always performed by the graft, while the other, individuation, fig.81.

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Über den Zustand des Glykogens in der Leber, im Muskel und in Leukocyten. (Zur Kenntnis der Proteinbindung physiologisch wichtiger Stoffe.)

Cited by 187 publications

References 0 publications

The dynamic life of the glycogen granule

The dynamic life of the glycogen granule

Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future

New Advances in the Chemistry and Biology of Organized Growth

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