über den wechselnden Gehalt des menschlichen Uterusmuskels an kontraktilen Proteinen

Characterization and Comparison of the Contractile Proteins from Human Gravid and Non-Gravid Myometrium

“…We did not find any increase of the contractile protein concentration during pregnancy, data in contradiction with those obtained by viscometry [1][2][3][4]. However, in those studies it was not taken into account that the higher viscosity observed may be due to a higher degree of association of actin and myosin as well as to a higher protein concentration; it is now actually stated that several factors may influence actomyosin enzymatic activity: e.g., new isoenzyme apparition [28] and degree of myosin phos phorylation or of calcium fixation [29,30], Using two-dimensional electrophoresis to characterize the different forms of the myometrium proteins, we have observed a pattern which looks like those stated by Gabbiani et al [8], Similarly to these authors we did find a spot corresponding to vimentin.…”

“…Since the work of Csapo [1] on rabbit myometrium, it has been well established that in both man [2] and animals [3,4] the concentration of contractile proteins in uterine muscle decreases in the absence of ovarian hormones, whereas it is restored by oestrogen treatment. An important increase has also been reported during pregnancy [1][2][3][4].…”

“…An important increase has also been reported during pregnancy [1][2][3][4]. In these studies the concentration of contractile proteins were obtained from the viscosity mea surement of uterine extracts whose exact protein composition was not known, since adequate analytical techniques were unavailable [5].…”

Tropomyosin im Myomgewebe

“…Es sei hier nur an die Bestimmung der kontraktilen Proteine durch Csapo [8], Necdham and Caivkwell [17], Schwalm, Cretius und Lange [22], Cretius [3], Schtvalm und Cretius [23] sowie Hasselbach und Ledermair [9,10] erinnert. Untersuchungen über die Energiedonatoren stam m en über wiegend von Caivkwell [2], von Cretius [4,5,6] und von Hasselbach und Ledermair [11].…”