Über den spezifischen Einfluß der Kohlensäure auf die Sauerstoffbindungskurve des Hämoglobins

Hermann, Hannes; Hudoffsky, B.; Netter, Hans; Travia, L.

doi:10.1007/bf01766660

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…These authors showed that Py, the oxygen pressure for y% saturation of horse Hb with 02, is about 1.4 times greater at pH7.37 in NaHCO3-CO2 solutions than in NaCl solutions of the same ionic strength (0.1 M). Their results were confirmned and extended in a comprehensive paper by Hermann, Hudoffsky, Netter & Travia (1939), who also gave a valuable review of previous work on the subject. Since 1950 the problem has been further investigated centration under these circumstances (see eqn.…”

Section: H++hc03 C02+h20supporting

confidence: 56%

Some recent work on the interactions of oxygen, carbon dioxide and haemoglobin

Roughton¹

1970

Biochemical Journal

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Section: H++hc03 C02+h20supporting

confidence: 56%

Some recent work on the interactions of oxygen, carbon dioxide and haemoglobin

Roughton¹

1970

Biochemical Journal

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“…Studying the effect of cations, Hill and Wolvekamp (30) found that in dilute solutions of hemoglobin in phosphate buffers the potassium buffer shifted the dissociation farther to the right than did the sodium buffer. The results of Sidwell and colleagues (28) and of Hermann and associates (29) indicate that the influence of the potassium ion is not great. Table II summarizes values found in the literature (31)(32)(33)(34)(35)(36)(37)(38)(39)(40) for the sodium, potassium and chloride concentrations within the red corpuscle.…”

Section: Methodsmentioning

confidence: 96%

“…They pointed out that at a pH of 6.8 carbamate formation of CO2 with hemoglobin does not occur. Hermann and col-leagues (29) have since shown that in the physiological range above 7.0 much of the bicarbonate effect can be attributed to the partial conversion of hemoglobin to a carbamino compound by reaction with free CO2. They found also that in the presence of bicarbonate and CO2 the effect of phosphate upon the oxyhemoglobin dissociation equilibrium almost disappeared.…”

Section: Methodsmentioning

confidence: 99%

The Position of the Oxygen Dissociation Curve of the Blood in Normal Children and Adults 1

Morse¹,

Cassels²,

Holder³

et al. 1950

J. Clin. Invest.

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Oxyhemoglobin dissociation curves were determined in normal children and adults as a preliminary to a study of such curves in patients with cyanotic congenital heart disease. A comparison of the curves of normal children with those of normal adults showed that the dissociation curves of children tend to lie to the right of those of the adult. In order to confirm this observation, the study was extended to include more cases and a wide range of ages. Thi-s report presents the results of the study.The report consists of a comparison between the positions of the oxyhemoglobin dissociation curves of the child and the adult in a group of 21 children two to ten years of age and 22 adults 21 to 45 years of age. In addition, it includes oxygen dissociation data for six newborn infants less than one day old, for a group of 15 older infants varying in age from 11 days to two years, and for a group of nine pre-adolescents, adolescents and post-adolescents from 11 to 20 years of age. The older infants were included in order to determine whether the slight shift of the curve to the right in childhood is greater in infancy. The older children were studied in the hope of determining the approximate age at which the leftward shift to the normal adult position occurs. on the dissociation curve, usually between 20 and 90 per cent saturation. The samples when drawn were mixed with heparin and kept in ice water. After equilibration they were stored in sampling tubes over mercury and were kept in ice water until the analyses for carbon dioxide and oxygen by the Van Slyke-Neill manometric method (2) were completed. Analyses were completed within eight hours after drawing the sample. The oxygen and carbon dioxide concentrations of the gas phase of the tonometers were determined by Haldane analysis. SUBJECTS AND METHODS SubjectsThe pH,, of each equilibrated sample was calculated from the Table I gives for both children and adults the means and their standard errors, the standard deviations of distribution, and the "t" values which were calculated to test the significance of observed differences between the means of the PO2 values of children and those of adults at given percentage saturations. Figure 1 shows

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