Über den papierchromatographisch ermittelten Gehalt von Phosphor-Verbindungen in der säurelöslichen Fraktion des menschlichen Blutes

Rohdewald, Margarete; Weber, Martha

doi:10.1515/bchm2.1957.306.1-2.90

Cited by 12 publications

(3 citation statements)

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“…Special attention has been given to the study of carbohydrate metabolism, which has shown consistent disturbances [Burch and Milunsky, 1969;Raiti et al, 1974;Sutnick et al, 1974;Yasuda et al, 19791. In particular, the levels of intermediates of the glyolytic pathway in trisomy 2 1 children have demonstrated consistent deviations from normal ranges. In agreement with previous data, which indicated a considerable fall of the erythrocyte ATP content [Rohdewald and Weber, 1965;Rohdewald and Weber, 1958;Rosner et al, 1965;Kedziora et al, 19721 have reported decreased levels of 2,3-diphosphoglyceric acid (2,3-DPG), and increased content of AMP, guanosine 5'-triphosphate (GTP) ,NADf, NADPf, inorganic phosphate (Pi) and hexose diphosphate (HDP). Different conclusions have been provided by a more recent study, which has shown that the concentrations of RBC adenine nucleotides AMP,ADP and ATP did not differ in DS from those of control subjects [Puukka et al, 19821. The present study of the RBC adenine nucleotides pattern in trisomy 21 has been carried out using a new method, which avoids possible interferences in the spectrophotometric assay of AMP and ADP.…”

Section: Discussionsupporting

confidence: 92%

Red blood cell adenine nucleotides abnormalities in down syndrome

Stocchi¹,

Magnani²,

Cucchiarini³

et al. 1985

Am. J. Med. Genet.

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The red blood cell adenine nucleotides of 20 Down Syndrome patients and 20 healthy controls were determined by a new high-performance liquid chromatography method. All patients showed increased concentrations of adenosine 5'-diphosphate (ADP) and adenosine 5'-monophosphate (AMP), while adenosine 5'-triphosphate (ATP), nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) were within normal ranges. This alternation of the energetic charge could be partly responsible for the impairment of glucose metabolism in these patients.

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Section: Discussionsupporting

confidence: 92%

Red blood cell adenine nucleotides abnormalities in down syndrome

Stocchi¹,

Magnani²,

Cucchiarini³

et al. 1985

Am. J. Med. Genet.

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“…The 2,3 DPG greatly facilitates the release of oxygen from hemoglobin because of the greater affinity of the compound for the deoxygenated form than for the oxygenated form. The 2,3 DPG content of the human fetal red cells may be lower than that of the adult erythrocytes [41]. I t seems that an increase in the formation of 2,3 DPG after birth is a possible regulator in decreasing the oxygen affinity of the red blood cells during this period.…”

Section: Discussionmentioning

confidence: 94%

Hemoglobin C in Newborn Sheep and Goats: A Possible Explanation for its Function and Biosynthesis

et al. 1969

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“…NADP as well as Pi was observed. Of the ndenine Special attention should be drawn to a considerable nucleotides, only the ADP content did not show any fall of the ATP content, which amounted to about change, whereas the amount of AMP increased twohalf its normal value [12,13,16]. The 2,3-DPG content fold.…”

Section: Discussionmentioning

confidence: 95%

Efficiency of the Glycolytic Pathway in Erythrocytes of Children with Down's Syndrome

et al. 1972

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ExtractThe intermediates of the glycolytic pathway were investigated in erythrocytes of children with Down's syndrome and the results achieved were compared with those obtained from healthy children of the same age. In the acid-soluble fraction obtained from the erythrocytes, the levels of the intermediates of the glycolytic pathway were determined. The adenine and guanine nucleotides, coenzymes, and inorganic phosphate (Pi) and some other intermediates were examined. The adenine nucleotides: adenosine 5'-monophosphatc (AMP), adenosine o'-diphosphate (ADP), adenosine o'-triphosphate (ATP) and the guanine nucleotide: guanosine fZ-triphosphate (GTP) were determined. The nicotinamide adenine dinueleotide (NAD) and nicotinamide adenine dinueleotide phosphate (NADP), two glycolytic pathway coenzymes, were examined. Hexose diphosphate (HDP) and 2 ,3-diphosphoglyceric acid (2,3-DPG) were tested.Three groups were distinguished after the determination of the karyotype in the children examined: group I, seven children with Down's syndrome and trisomy G (karyotype 47,XX,G + or 47,XY,G +); group II, two children (siblings) with Down's syndrome and G/G translocation (karyotype 46,XX,G -,t(GqGq) +mat or 46,XY, G -,t(GqGq) +mat); and group III, healthy children with a normal karyotype, corresponding to the sex. The results of the biochemical investigations in all of the three groups were compared.Taking the values obtained for the healthy children as standard, a considerable decrease in the levels of ATP and 2 ,3-DPG and an increase in the levels of AMP, GTP, NAD, NADP, Pi, and HDP were noticed in the group of children with Down's syndrome and trisomy G. The ADP concentration was the same as in the control group. The values of some intermediates obtained for the group of mongols with unbalanced translocation G/G were approximately the same as the values obtained for the group of mongols with trisomy G. The 2 ,3-DPG level was just as low as in the mongol group with trisomy G.The results of the calculations, developed by means of the Student test, are statistically significant. Speculation

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Über den papierchromatographisch ermittelten Gehalt von Phosphor-Verbindungen in der säurelöslichen Fraktion des menschlichen Blutes

Cited by 12 publications

References 0 publications

Red blood cell adenine nucleotides abnormalities in down syndrome

Red blood cell adenine nucleotides abnormalities in down syndrome

Hemoglobin C in Newborn Sheep and Goats: A Possible Explanation for its Function and Biosynthesis

Efficiency of the Glycolytic Pathway in Erythrocytes of Children with Down's Syndrome

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