Über den nachweis einer wirkung von vitamin K1in vitro auf die oxydative phosphorylierung

Martius, C.; Nitz-Litzow, D

doi:10.1016/0006-3002(54)90317-0

Cited by 42 publications

(1 citation statement)

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“…The mechanism responsible for the decrease of in vitro tissue factor generation is not clear but could be due to a direct effect of warfarin on cellular function (for example, unrer, coupling of oxidative phosphorylation, 'M. inhibition of mitosis, cell killing) (14), or ,ted interference with vitamin K-dependent on)s y-carboxylation of glutamic acid resiion dues in an intermediary protein or in tissue factor itself (15).…”

mentioning

confidence: 99%

Delayed Hypersensitivity in Man: Effects of Systemic Anticoagulation

Edwards

Rickles

1978

Science

107

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Skin test reactivity, lymphocyte transformation, and mononuclear cell tissue factor generation were evaluated both before and during systemic anticoagulation in 24 volunteers. Anticoagulation with warfarin decreased skin test induration and tissue factor generation, but lymphocyte trnasformation remained unchanged. An intact coagulation mechanism, including tissue factor generation, appears to be important for the development of skin test induration in humans.

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mentioning

confidence: 99%

Delayed Hypersensitivity in Man: Effects of Systemic Anticoagulation

Edwards

Rickles

1978

Science

107

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Decompensated Portal Cirrhosis

Ballard¹

1966

Arch Intern Med

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Techniques for inhibiting tumor metastases

Hoover¹,

Ketcham²

1975

Cancer

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Of the four major biological mechanisms of cancer spread, hematogenous dissemination is perhaps the most significant, as it usually heralds a fatal outcome for the patient. Recent experimental approaches have shown ways of altering the metastatic process and even totally inhibiting it in some animal models. It appears that these models may be applicable to certain human cancers. To prevent hematogenous metastasis formation the process must be inhibited at any one of four levels: 1) growth of the primary; 2) invasion of vessel walls; 3) release of viable tumor cells; or 4) entrapment and growth in distant organs. Judicious handling of the primary can decrease metastasis by minimizing the shedding of tumor cells. New experimental agents prevent the release of tumor cells from the primary by normalizing the blood vessels of the tumor. Warfarin, heparin, and fibrinolytic agents inhibit the entrapment of circulating tumor cells, presumably by their effect on coagulative mechanisms. A better understanding of the benefits of combined approaches to cancer using chemotherapy, irradiation, and immunotherapy, alone and as adjuncts to surgery, offers new opportunity to study methods of controlling metastatic disease.

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Über den nachweis einer wirkung von vitamin K1in vitro auf die oxydative phosphorylierung

Cited by 42 publications

References 2 publications

Delayed Hypersensitivity in Man: Effects of Systemic Anticoagulation

Delayed Hypersensitivity in Man: Effects of Systemic Anticoagulation

Decompensated Portal Cirrhosis

Techniques for inhibiting tumor metastases

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