Über den Nachweis der Wirkung der Expektorantien

Gordonoff, T.; Merz, Hartmut

doi:10.1007/bf01737040

Cited by 19 publications

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“…Important question is if no other requirement in the qualification of thyme preparations should be desired. GORDONOFF and MERZ [1] and GORDO-NOFF and JANE-I-r [2] observed that thymol and thyme oil acted as secretomotoric and desinfectant agents. VOLLMER [3] confirmed this observation, but recognized also a secretolytic activity of expectorantia which contain saponins.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological and Chemical Investigation of Thyme Liquid Extracts

Broucke¹,

Lemli²

1981

Planta Med

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Thymks vulgaris L. and Thymus ser-py1lun L. are used as antitussive remedies. Liquid thyme extracts have been studied in vitro for spasmolytic activity on the smooth muscles of the guinea-pig trachea and ileum. Treatment of the carbachol induced tracheal strip with thyme extracts resulted in relaxation of this preparation. Ileum contractions due to acetyicholine, were reduced in the same proportion. Thymol and carvacro! content was determined with HPLC. Phenol concentration of examined extracts was very low ( 0.001 %) and could not be responsible for antispasmodic activity. However, thymol and carvacrol in sufficient dose were found to have tracheal relaxant properties. pD2, intrinsic activity and relative potency to DL-isoprenaline of both of isomers were determined. Laboratorium voor Farmacognosie, Jnstituut voor Farmaceutische Wetenschappen, Katholieke Llnzverszteit te Leuven, Van Evenstraat 4, B-3000 Leuven, Belgium Downloaded by: NYU. Copyrighted material.

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Section: Introductionmentioning

confidence: 99%

Pharmacological and Chemical Investigation of Thyme Liquid Extracts

Broucke¹,

Lemli²

1981

Planta Med

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“…Experimental evidence suggests that thyme oil has secretomotoric activity (Gordonoff and Merz, 1931). This activity has been associated with a saponin extract from T. vulgaris (Vollmer, 1932).…”

Section: Expectorant and Secretomotoric Activitiesmentioning

confidence: 99%

Study on the assessment of plants/herbs, plant/herb extracts and their naturally or synthetically produced components as ‘additives’ for use in animal production

Vienna

Graz

Hohenheim

et al. 2007

EFS3

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A As ss se es ss sm me en nt t o of f p pl la an nt ts s/ /h he er rb bs s a an nd d e ex xt tr ra ac ct ts s I In nt tr ro od du uc ct ti io on n 5 5 M Mo on no og gr ra ap ph hs s o of f t th he e f fo ol ll lo ow wi in ng g s sp pe ec ci ie es s: : FOREWORDIn September 2003 the European Parliament and the Council of the European Union adopted the Regulation No. 1831/2003 on additives for use in animal nutrition. The purpose of this regulation is to establish a Community procedure for authorising the placing on the market and use of feed additives and to lay down rules for the supervision and labelling of feed additives and premixtures in order to provide the basis for the assurance of a high level of protection of human health, animal health and welfare, environment, and "users and consumers" interests in relation to feed additives, whilst ensuring the effective functioning of the internal market. Under the current regulation detailed guidelines for some family of products are completely missing, that it is the case of the plants/herbs, plant/herb extracts and their naturally or synthetically produced components. For this reason it is one of the priorities of the FEEDAP Panel to implement guidelines/guidance for these types of compounds.It has been observed that plant/herbs and their extracts are increasingly being used (and informally marketed) not only as sensory additives, but also for other purposes not covered by the legislation, notably better growth or feed conversion, improved meat quality, and for prophylactic purposes. There are strong indications that such use will further increase as replacement additives for the antibiotic growth promoters whose use will be prohibited by the end of 2005.Nowadays, a compiled list of these compounds or extracts does not exists although the European Federation of Animal Feed Additive Manufacturers (FEFANA) notes that some 280 plant extracts and a further 1700 chemically defined compounds have been used within Member States as sensory additives in animal feeds.The results of this study will be used by EFSA, in consultation with the European Commission, Member States and other stakeholders, to provide input for the development of guidance/guidelines documents for the authorisation of plants/herbs, plant/herb extracts and their naturally or synthetically produced components for use in animal nutrition. ASSESSMENT OF PLANTS/HERBS, PLANT/HERB EXTRACTS AND THEIR NATURALLY OR SYNTHETICALLY PRODUCED COMPONENTS AS "ADDITIVES" FOR USE INTRODUCTIONThe last two decades have seen a substantial increase in use of herbs/botanicals and their products not only as herbal medicinal products and for food supplements, but also in the field of animal nutrition. The use of herbal feed additives, which include essential oils and (exotic) herbal mixtures, is extensively promoted by the producers, but the scientific background underpinning their use often is limited. Consequently an adequate knowledge of quality control (content of active substance(s) stability), efficacy and safety is oft...

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Röntgenkontrastmittel

Hecht

1939

Handbuch Der Experimentellen Pharmakologie

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Über den Nachweis der Wirkung der Expektorantien

Cited by 19 publications

References 0 publications

Pharmacological and Chemical Investigation of Thyme Liquid Extracts

Pharmacological and Chemical Investigation of Thyme Liquid Extracts

Study on the assessment of plants/herbs, plant/herb extracts and their naturally or synthetically produced components as ‘additives’ for use in animal production

Röntgenkontrastmittel

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