Über den Einfluss von Natriumsulfit, Natriumtellurit und Natriumselenit auf die Retention von Zink, Kadmium und Quecksilber im Organismus

Eybl,; J, S ykora; Mertl, F

doi:10.1007/bf01900784

Cited by 9 publications

(3 citation statements)

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Section: Retention and Excretionmentioning

confidence: 99%

“…Combined single parenteral exposure of rats to mercuric mercury and selenite or selenate causes an increase of whole-body retention of mercury as compared to what happens in animals not treated with selenium (3,39). The whole-body elimination rate (39) and the elimination of mercury in urine and feces are decreased (4,40,41). Stillings et al (26) found a slight decrease of fecal and urinary excretion of mercury in rats fed 15 mg Hg as methylmercury and 0.6 mg Se as selenite/kg food for 4 weeks as compared to animals not fed additional selenium.…”

Section: Retention and Excretionmentioning

confidence: 99%

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Interaction between selenium and methylmercury.

Skerfving¹

1978

Environ Health Perspect

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The available data on the influence of selenium on the toxicity of methylmercury and of methylmercury on selenium as a nutrient and toxic agent are reviewed. Selenium as selenite has a relative protective effect on acute and subacute toxicity of methylmercury in the rat and the quail. The protective mechanism is far from clear. Of special interest is the fact that selenium-treated animals may remain unaffected, even when they have attained tissue mercury levels otherwise associated with toxic effects. Selenite causes some increase of tissue mercury levels in methylmercury-exposed animals. On the other hand, methylmercury induces a remarkable enhancement of organ concentrations of selenium in animals given selenite. The interaction between selenium and methylmercury is in many ways different from that between selenium and inorganic mercury, and also from that between selenium and other metals. Due to the considerable interspecies differences in the toxicity of methylmercury, the available data do not allow conclusions on interactions in man. Practical implications of a possible protective effect of selenium on methylmercury toxicity in humans are discussed.

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Section: Retention and Excretionmentioning

confidence: 99%

Section: Retention and Excretionmentioning

confidence: 99%

Interaction between selenium and methylmercury.

Skerfving¹

1978

Environ Health Perspect

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“…Several authors (1,(8)(9)(10)(11) have demonstrated that if selenium is given in equimolar doses together with mercuric mercury, this has, in the rat, a protective effect against nephrotoxicity. Selenium administration is combined with a changed distribution of mercury, with increasing amounts in blood and in liver, and an increase in total body retention of mercury.…”

Section: Selenium Interaction With Mercuric Mercury Toxicitymentioning

confidence: 99%

Interaction between selenium and inorganic mercury.

Berlin¹

1978

Environ Health Perspect

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Data on mercury and selenium interaction in the mammalian body are reviewed. Experimental data from studies on rats show that selenium Interacts with mercury metabolism and toxicity after exposure to mercuric mercury. Autopsy data from workers exposed to mercury vapor indicate an association between mercury and selenium retention in the central nervous system, suggesting the formation of a mercuryselenium complex. In animal experiments, mercuric mercury interferes with selenium metabolism and toxicity. Available data do not, at present, permit deduction as to whether additional selenium Intake in man, exposed to mercury vapor or mercuric mercury, will have any effect, beneflcial or adverse.

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