Über den Einfluß oral applizierter Triglyceride auf die Muskelproteolyse bei der Ratte

Abstract

Earlier studies in man could demonstrate that intravenous lipids decreased the concentration of amino acids in plasma (to 50%). In short- and long-term experiments in rat the effect of orally applied olive-oil on the concentration of amino acids in blood, on the excretion of 3-methylhistidine and of total nitrogen into urine was measured. Two control groups were used: rats with total restriction of food and rats which were fed ad libitum. 2 ml olive-oil given to rats within 12 hours decreased the concentration of alanine, valine, leucine, isoleucine. Whereas food restriction increased the excretion of 3-methylhistidine into urine and the blood concentration of leucine, isoleucine, valine, tyrosine, phenylalanine, threonine, and glutamine, the oil-fed rats showed no increase of amino acid levels in plasma and no increase of 3-methylhistidine excretion into urine. These experiments suggest that lipid application inhibits proteolysis in muscle, and thus diminishes the amino acid levels in blood.