Über den Einfluß induzierender Substanzen auf Fremdstoff-Oxydasen und andere Redoxenzyme der Leber

Koransky, W.; Magour, S.; Noack, G.; Hermann, R. Schulte

doi:10.1007/978-3-662-39718-3_148

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“…The rate of microsomal aminopyrine demethylation (measured as an index of mono-oxygenase activity), organ size and DNA content were considerably increased 10 days after treatment with this agent (Fig. 1, left) as was shown before (Koransky et al, 1969;Schlicht et al, 1968). However, 5 weeks after treatment when the inducer is essentially eliminated (half-life of a-HCH in the rat is about 7 days; Koransky & Portig, 1963) the changes in enzyme activity and organ mass had disappeared almost completely whereas the DNA content of the liver was still increased (Fig.…”

Section: Biochemical Determinationssupporting

confidence: 67%

Feedback Inhibition of Hepatic Dna Synthesis

Schulte‐Hermann

Schmitz

1980

Cell Proliferation

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α‐Hexachlorocyclohexane (α‐HCH) and some other xenobiotic inducers were used to elicit adaptive increases in mono‐oxygenase activity, size and DNA content of rat liver. After elimination of the inducers, organ size and mono‐oxygenase activity returned to normal whereas the DNA content of the liver remained increased. Upon renewed treatment with an inducer the adaptive responses uncoupled. While mono‐oxygenase induction and liver enlargement did occur, DNA replication was largely suppressed. These findings show that in the hyperplastic state the liver is resistant to stimulation of DNA synthesis by the inducers. It is concluded that the DNA content of the liver (or the number of liver cells) is controlled by a feedback system which monitors an excess of DNA (cells) and suppresses cell replication if the content of DNA exceeds the normal level. Organ mass has little, if any, effect on the operation of this feedback system.

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Section: Biochemical Determinationssupporting

confidence: 67%