Über den Einfluß des Gehirns auf die Wärmeregulation

Isenschmid, R.; Krehl, L.

doi:10.1007/bf01873889

Cited by 101 publications

(4 citation statements)

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“…Following the discovery of neural foci in the preoptic posterior hypothalamus responsible for HP (21) and in the preoptic anterior hypothalamus responsible for heat dissipation (1), Meyer (33) suggested that regulation of body temperature may be achieved by coordinated activity of these two centers; namely, that the activity of the posterior center preventing Fig. 3.…”

Section: Thermoregulation In Humans As Influenced By Thermal Factorsmentioning

confidence: 99%

Contribution of thermal and nonthermal factors to the regulation of body temperature in humans

Mekjavic

Eiken²

2006

Journal of Applied Physiology

158

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The set point has been used to define the regulated level of body temperature, suggesting that displacements of core temperature from the set point initiate heat production (HP) and heat loss (HL) responses. Human and animal experiments have demonstrated that the responses of sweating and shivering do not coincide at a set point but rather establish a thermoeffector threshold zone. Neurophysiological studies have demonstrated that the sensor-to-effector pathways for HP and HL overlap and, in fact, mutually inhibit each other. This reciprocal inhibition theory, presumably reflecting the manner in which thermal factors contribute to homeothermy in humans, does not incorporate the effect of nonthermal factors on temperature regulation. The present review examines the actions of these nonthermal factors within the context of neuronal models of temperature regulation, suggesting that examination of these factors may provide further insights into the nature of temperature regulation. It is concluded that, although there is no evidence to doubt the existence of the HP and HL pathways reciprocally inhibiting one another, it appears that such a mechanism is of little consequence when comparing the effects of nonthermal factors on the thermoregulatory system, since most of these factors seem to exert their influence in the region after the reciprocal cross-inhibition. At any given moment, both thermal and several nonthermal factors will be acting on the thermoregulatory system. It may, therefore, not be appropriate to dismiss the contribution of either when discussing the regulation of body temperature in humans.

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Section: Thermoregulation In Humans As Influenced By Thermal Factorsmentioning

confidence: 99%

Contribution of thermal and nonthermal factors to the regulation of body temperature in humans

Mekjavic

Eiken²

2006

Journal of Applied Physiology

158

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“…Meyer (1913) had postulated two coupled nerve centres, one thermogenic, and the other thermolytic, with reciprocal inhibition. A posterior hypothalamic site at which afferent and efferent pathways for shivering are connected in the central nervous system was discovered by Isenschmid & Krehl (1912). Destruction of the tissues surrounding this ' centre' did not eliminate shivering (Isenschmid & Schnitzler, 1914), but the destruction of this area itself eliminated metabolic responses to cold while leaving the physical responses to heat unimpaired (Keller & Hare, 1932;Keller, 1933;Kanson & Ingram, 1935).…”

Section: The Influence Of Anaesthetic Agents Upon Thermoregulationmentioning

confidence: 99%

The Thermosensitivity of the Hypothalamus and Thermoregulation in Mammals

Bligh

1966

Biological Reviews

210

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“…History.-M. R., a single man, aged 31, Jewish, born in Russia, was admitted to the Montefiore Hospital on Jan. 5,1933. He had been well until 11 years of age, when bilateral progressive loss of vision developed.…”

Section: Report Of a Casementioning

confidence: 99%