Über das Thyreotrope Hormon des Hypophysenvorderlappens

Junkmann, K.; Schoeller, W. R.

doi:10.1007/bf01766365

Cited by 111 publications

(8 citation statements)

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“…The Junkman-Schoeller assay (27), for example, was based on histological changes in the guinea pig thyroid, and these were difficult to quantify. Roy 0.…”

Section: Discovery Of Tshmentioning

confidence: 99%

Thyroid-Stimulating Hormone: Biosynthesis, Cell Biology, and Bioactivity

Magner¹

1990

Endocrine Reviews

160

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“…The Junkman-Schoeller assay (27), for example, was based on histological changes in the guinea pig thyroid, and these were difficult to quantify. Roy 0.…”

Section: Discovery Of Tshmentioning

confidence: 99%

Thyroid-Stimulating Hormone: Biosynthesis, Cell Biology, and Bioactivity

Magner¹

1990

Endocrine Reviews

160

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“…As this extract was still relatively crude as compared with extract (2), the possible presence in it of other factors acting on the metabolism cannot be excluded ; (2) a growth hormone extract obtained by Dr. Freud, Amsterdam, which was much more purified and contained 1 unit in 6 µg. ; (3) a thyrotrophic extract, completely free from gonadotrophic and corticotrophic hormone and containing 20 guinea-pig units [Junkmann & Schöller, 1932] per mg.; (4) a corticotrophic extract, completely free from thyrotrophic and gonadotrophic hormone, containing 3 units [Reiss, 1936] in 1 mg. ; (5) a gonadotrophic extract, obtained from serum of pregnant mares, containing 40 units (oestrus-producing units) in 1 mg. Table I shows the extent of the specific dynamic action after admini¬ stration of a certain quantity of protein in normal rats and in rats before and at certain periods after hypophysectomy. In untreated rats the oxygen consumption may increase up to 40% above the normal.…”

Section: Methodsmentioning

confidence: 99%

Influence of the Pituitary Anterior Lobe Upon the Specific Dynamic Action of Protein

Reiß¹

1940

Journal of Endocrinology

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The results obtained in the numerous experiments dealing with the influence of hormones on the specific dynamic action of protein are extremely contradictory ; even the simple question as to how the specific dynamic action of protein is influenced by pathological states of hypo\ x=eow-\ and hyper-thyroidism has not been answered satisfactorily [Serejski & Jisslin, 1930]. Abelin [1923] reports an increase in the specific dynamic action of protein after administration of thyroid extracts, while Feuling [1933] and Schittenhelm & Eisler [1932] observe a decrease after administration of thyrotrophic hormones. The reports on the specific dynamic action in hypophyseal pathology are especially conflicting. Plaut [1922 a, b], Liebesny [1925], Kestner, Liebesch\l=u"\tz-Plaut & Schadow [1926] and Peters [1930] found a decreased specific dynamic action of protein in pituitary hypofunction. Fulton & Cushing [1932] and Johnston [1932] were, however, unable to observe any change in patients with disturbed hypophyseal function. Gaebler [1929] found the specific dynamic action of protein unchanged in a hypophysectomized dog. According to Foster & Smith [1926] the specific dynamic action of glycocol is decreased in hypo¬ physectomized rats, though Evans, Luck, Pencharz & Stover [1938] found it unchanged.The present experiments were carried out in order to study systematically the specific dynamic action of protein in rats at certain times after hypophysectomy and also the influence of some of the well-known hormones of the pituitary anterior lobe on the specific dynamic action. MethodsThe animals used were adult Wistar rats, weighing 120-180 g. Hypo¬ physectomy was performed by the paratracheal route and only those experiments were considered where removal of the hypophysis could be regarded as complete.The animals were not given any food for 10-14 hours before the experi¬ ments were started. The basal metabolism of these fasting animals was determined for two or three normal periods, then fresh egg albumen was administered. This was given orally by means of a Record syringe with an

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“…To concentrate the thyrotropic hormone from these extracts many fractionation techniques have been tried, such as alcohol or acetone (139,140), salt (139,145) or protein precipitants (121,141,142,147,148). It is of great interest to note that the thyrotropic prin ciple is soluble in the solution of some protein precipitating agents, namely, trichloroacetic acid, sulfosalicylic acid, lead acetate etc.…”

Section: Anterior Pituitarymentioning

confidence: 99%

“…Both acid (139,140,141) and alkaline (142 to 145) extracts of · pituitary tissue have been used for the preparation of the thyro tropic substance; saline extraction (138,146) is also applicable. To concentrate the thyrotropic hormone from these extracts many fractionation techniques have been tried, such as alcohol or acetone (139,140), salt (139,145) or protein precipitants (121,141,142,147,148).…”

Section: Anterior Pituitarymentioning

confidence: 99%

The Chemistry of the Hormones

Li¹

1947

Annu. Rev. Biochem.

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ADRENAL Venning et al. (1, 2) developed a method for the assay of urinary corticosteroid'like substances based upon the glycogen deposition in the livers of glucose treated adrenalectomized mice. A glycogenic unit is defined as the equivalent of the biological activity of 1 p.g. of 17-hydroxy-ll-dehydrocorticosterone. It was pointed out by these workers that the administration of glucose increased the sensitivity of the test many times. Similar assay methods have also been described by Dorfman et al. (3) and Eggleston et al. (4) using adrenalectomized mice without glucose treatment. Dorfman et al. (5) reexamined the cold test of Selye & Schenker (6) for the bioassay of urinary corticoids and found that the method was not practical for extended routine use.Two chemical methods for the determination of the urinary corticosteroid-like substances have also appeared. Heard & Sobel (7) introduced a color metric method, based on the reducing sugar like property of the adrenal cortical hormones, for the quantitative estimation of these steroids; the color was produced by the reduc tion of phosphomolybdic acid to molybdenum blue in glacial acetic acid. The reaction is given by steroids containing a primary or secondary (but not tertiary) , a-ketol grouping, an a, ,B-unsatu rated 3-ketone group, or both. Thus, desoxycorticosterone exhibits the strongest reducing properties. The method has applied to the estimation of urinary neutral lipide soluble reducing substances as an index of adrenal cortical function (8) and reveals a good agree ment between results obtained by this chemical method and that by the bioassay technique of Venning et al. (1). The method of Lowenstein et al. (9) in determining cortico steroids in urines is based on period ate oxidation of the primary alcohol group at C21 which yields one mole of formaldehyde per 1 This review includes the following subjects: adrenals, gonads, insulin, and anterior pituitary. Due to the limitation of space, other topics have been omitted. 291 Annu. Rev. Biochem. 1947.16:291-322. Downloaded from www.annualreviews.org Access provided by University of Sussex on 02/07/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

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Über das Thyreotrope Hormon des Hypophysenvorderlappens

Cited by 111 publications

References 1 publication

Thyroid-Stimulating Hormone: Biosynthesis, Cell Biology, and Bioactivity

Thyroid-Stimulating Hormone: Biosynthesis, Cell Biology, and Bioactivity

Influence of the Pituitary Anterior Lobe Upon the Specific Dynamic Action of Protein

The Chemistry of the Hormones

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