Über das rhythmische Wachstum der Zellen durch Verdopplung ihres Volumens

Jacobj, Walther

doi:10.1007/bf02079531

Cited by 262 publications

(10 citation statements)

References 14 publications

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“…Calculation of the nuclear volumes in liver cells of rat and mouse produces a curve with several peaks, to which the maxima of the frequencies are related as 1:2:4:8 [9], The relationship of nuclear size to ploidy is not a direct one, since DNA represents only 28.8 % of the con tents of rat liver nuclei [10]. Many investiga tions, however, suggest that doubling of the DNA content in liver nuclei is roughly re flected by a doubling of nuclear volume [11].…”

Section: Nucleimentioning

confidence: 99%

Liver Architecture

Sasse

Spornitz

Maly

1992

Enzyme

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The development of liver parenchyma starts from entodermal cells which grow out from the gut into the mesenchyma of the septum transversum. In the definitive organ this close association of epithelial cells (hepatocytes) and mesenchyma-derived nonparenchymal cells is maintained. The liver, and with it each hepatocyte, acts in two directions; the vascular poles of the hepatocytes serve in an ingestive sense, while at their biliary poles secretory functions are exerted. Hepatic microvascularization comprises two afferent vessels (arterial and portal terminal branches), the sinusoids and the terminal hepatic venule. Sinusoidal cells surround the capillaries but also have highly specialized functions with regard to filtration, phagocytosis, fat storage and defense. The autonomic innervation plays an important role in the regulation of metabolic functions. Above the cellular level the proper architecture of the liver parenchyma has been the object of controversial discussions for centuries. The concept of the liver lobule, the portal unit, the liver acinus and other structures are presented and discussed. Finally, the liver parenchyma is described as an irregular interdigitating system of regions related to the terminal blood vessels.

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Section: Nucleimentioning

confidence: 99%

Liver Architecture

Sasse

Spornitz

Maly

1992

Enzyme

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“…The exceptionally high value for external orbital glands and the somewhat higher values for livers of older rats are presumably due to appearance of greater numbers of tetraploid, octaploid, and even higher polyploid nuclei in these tissues, with advancing age (9,20). The large polyploid nuclei in these tissues can be recognized microscopically and presumably contain more DNA than diploid nuclei in accordance with their greater numbers of chromosomes, as shown by Ris and Mirsky (17).…”

Section: Discussionmentioning

confidence: 99%

“…The data afford no evidence that the amount of DNA in each set of chromosomes is not a constant, in all normal, precancerous, or tumor ceils o f the rat. Theoretically, the relations between diploid and polyploid cells of a given type are analogous to those between monomeric, dimeric, and polymeric molecules (9). Therefore the DNA content of an organ or tumor may be considered to be a measure of the number of its diploid cell units.…”

Section: Discussionmentioning

confidence: 99%

Polyploidy and Cancer

Cunningham

Griffin

Luck

1950

Journal of General Physiology

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The average desoxypentosenucleic acid content of individual nuclei was determined for various normal and tumor tissues, and for livers showing precancerous changes, in the rat. With certain exceptions attributable to polyploidy, the values were practically indistinguishable from each other and from values reported for cell nuclei of other mammals. The amount of this nucleic acid in diploid cells of the rat appears to be a constant, nearly equal to 6 x 10–6 micrograms. Findings of increased concentrations of this nucleic acid in tissues showing preneoplastic or neoplastic changes therefore confirm histological observations of increased cellularity and polyploidy in such tissues.

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“…Some authors have claimed that the method of proliferation is amitotic (Milne 1909, Munzer 1923, Jacobj 1925, Clara 1931, Szittyay 1937. In the present study evidence of amitosis has never been observed in either the growing embryonic liver or the restoring adult liver.…”

Section: Discussionmentioning

confidence: 99%

A Study of the Somatic Chromosomes of Rats

Tanaka

1953

CYTOLOGIA

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Über das rhythmische Wachstum der Zellen durch Verdopplung ihres Volumens

Cited by 262 publications

References 14 publications

Liver Architecture

Liver Architecture

Polyploidy and Cancer

A Study of the Somatic Chromosomes of Rats

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