Über das Auftreten Eines Brunststoffes in Blut und Geweben Unter Pathologischen Verhältnissen

Synthetic Estrogens and the Relation Between their Structure and their Activity.

“…After rats had been injected with estrogenically equivalent amounts of estrogens, stilbestrol was recovered in 25 per cent from the body and in equal amounts from the excreta; the esters of natural estrogens behaved similarly, while only 1 to 2 per cent of the administered estrone was found in the body and none in the excreta. Silberstein and coworkers (191) had previously shown in vitro that estrone is inactivated by liver tissue as well as by blood of dogs. Consequently it was generally accepted that the process of estrone inactivation took place in the liver, possibly involving an enzyme, and that the stability of stil- bestrol within the organism was due to the inability of the liver to inactivate the synthetic compound.…”