Über das Auftreten der sogenannten “Weidekrankheit” bei Kühen in Österreich im Zusammenhang mit Düngung und Fütterung

Köhler, Hans; Libiseller, R.

doi:10.1111/j.1439-0442.1970.tb00787.x

Cited by 25 publications

(5 citation statements)

References 82 publications

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“…Only one of the sheep examined showed hyperphosphatemia, and the serum concentrations of Ca were within normal concentrations in all sheep. Hypercalcemia and hyperphosphatemia were the results of remarkable changes in vitamin D poisoning (Mello 2003); these conditions have also been reported in cattle spontaneously poisoned by Trisetum flavescens (Köhler & Libiseller 1970) and Cestrum diurnum (Durand et al 1999), as well as in experimental poisoning by Solanum glaucophyllum in cattle (Döbereiner et al 1971) and N. veitchii in sheep (Riet-Correa et al 1993).…”

Section: Discussionmentioning

confidence: 87%

Enzootic calcinosis in sheep in Uruguay: a brief review and report of two outbreaks

et al. 2020

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This study aimed to do a brief review of enzootic calcinosis in sheep and to report two outbreaks of Nierembergia rivularis poisoning in sheep in Uruguay. The outbreaks occurred in farms located on an island (Outbreak A) and on the border (Outbreak B) of the Rincón del Bonete lake. Sheep of all ages were affected, with the exception of suckling lambs. The first clinical signs occurred in early October, and deaths occurred from December to February. Outbreaks A and B had morbidity of 10%, and the mortality was 7.2% and 2.8% in Outbreaks A and B, respectively. The clinical signs included weight loss, retracted abdomen, stiff gait, and kyphosis. An autopsy was performed on one sheep from each outbreak. Pulmonary and arterial calcification, nephrocalcinosis, and osteopetrosis were observed in gross and microscopic examination in both sheep. Thyroid C-cell hyperplasia and carcinoma was observed in sheep A. Sheep B showed thyroid C-cell hyperplasia and parathyroid chief cell atrophy. The parathyroid was not examined in the sheep from Outbreak A. The differential diagnosis of enzootic calcinosis in southern South America should consider four toxic plants in the Solanaceae family: Solanum glaucophyllum, Solanum stuckertii, Nierembergia veitchii, and Nierembergia rivularis.

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Section: Discussionmentioning

confidence: 87%

Enzootic calcinosis in sheep in Uruguay: a brief review and report of two outbreaks

et al. 2020

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“…Die Befunde an diesen Rindern haben Eingang in die Veroffentlichung von KOHLER und LIBISELLER (1970) gefunden. Diese Rinder bedurfen aber einer erneuten Betrachtung im Zusammenhan mit der hier zu erorternden Fragestellung.…”

Section: Rinder Die Im Winter An Kalzinose Erkranktenunclassified

“…DIRKSEN u.Mitarbeitern (1970), HANICHEN u. Mitarbeiter (1970), und DAMMRICH u. Mitarbeiter (1970 beschrieben worden sind. Es sei daher erlaubt, beispielhaft die Rinder 2.1.1.1. und 2.1.1.2. zu beschreiben, zumal hierdurch die vonKOHLER und LIBISELLER (1970) erhobenen Befunde eine Erganzung erfahren konnen. Das Rind 2.1.1 .l.…”

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Zur Kalzinose des Rindes

Köhler

Leibetseder

Libiseller

et al. 2010

Zentralblatt Für Veterinärmedizin Reihe A

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Zusammenfassung Rinder, die an Kalzinose erkrankt gewesen sind, können zwar eine Besserung des klinischen Krankheitsbildes erfahren. Die pathologisch‐anatomischen Veränderungen sind auch 4 Jahre nach Absetzen der toxischen Noxe vorhanden. Die Bezeichnung “Weidekrankheit” sollte zugunsten der Bezeichnung “Kalzinose” fallengelassen werden, da Rinder auch nach Aufnahme von Heu an dieser Krankheit erkranken können, ohne im Sommer inkriminierte Weiden aufgesucht zu haben. In der Compartment‐Analyse des P‐Stoffwechsels konnte nachgewiesen werden, daß Rinder, die mehrmals an Kalzinose erkrankt waren, der toxischen Noxe aber seit Monaten nicht mehr ausgesetzt waren, eine hohe P‐Retentionsrate aufweisen, die ihren Niederschlag nicht nur im Knochen, sondern auch im Weichgewebe findet. Morphologisch konnten bei diesen Tieren übermäßige Verkalkung der Knochen und ausgedehnte Verkalkung im kardio‐vaskulären System gefunden werden. Während der Untersuchung wurden unter den Bedingungen der Versuchsanstellung pro Tier und Tag durchschnittlich 26,6 g P abgelagert. Die Pathogenese und der Wirkungsmechanismus werden im Hinblick auf die Parathyreoidea und das Thyrocalcitonin diskutiert. Summary Calcinosis in cattle I. Studies on the pathology and metabolism of cattle with repeated attacks of calcinosis Cattle affected with calcinosis can show improvement in the clinical signs. The pathological changes may still be present 4 years after recovery from the toxic effects. The term “pasture disease” should be dropped in favour of “calcinosis” since cattle also contract the disease in winter without having grazed incriminated pastures during the preceding summer. Compartment‐analysis of P metabolism showed that cattle which had had several attacks of calcinosis but which had had no access to the toxic agent for some months had a high P retention in which the depot for storage was not only the bones but also the soft tissues. Such animals showed not only excessive calcification of the bones but also Ca deposits in the cardiovascular system. During the study there was deposition of a mean of 26.6 g. P per animal per day. The pathogenesis of the condition is discussed in relation to the parathyroids and thyrocalcitonin. Résumé A propos de la calcinose chez le bovin I. Recherches sur la pathologie et le métabolisme du phosphore chez des bovins atteints à plusieurs reprises de calcinose Les bovins ayant souffert de calcinose peuvent à vrai dire présenter une amélioration de l'image clinique de la maladie. Les changements anatomopathologiques sont présents 4 ans après cessation des effets toxiques. La désignation “maladie de l'herbage” devrait être abandonnée au profit de “calcinose”, étant donné que des bovins présentant également cette maladie sans avoir fréquenté les prairies incriminées. L'analyse du métabolisme du phosphore a montré que des bovins, plusieurs fois atteints de calcinose mais exempts des effets toxiques depuis des mois, présentent un taux de rétention du phosphore élevé dont le dépôt se trouve non seulement dans le squelette ...

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“…Arterial mineralization of both elastic and muscular arteries is a hallmark of enzootic calcinosis in ruminants. 28 Most reports of enzootic calcinosis in domestic herbivores showed mineralization of tunica intima and media of elastic arteries, which was associated with osteochondroid metaplasia in the tunica media since the early last century 3,8,10,11,12,21,22,23,27,34,35,44,45 and in more recent literature. 28,36,37 However, reports on enzootic calcinosis in muscular arteries are uncommon.…”

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confidence: 99%

Poisoning by Nierembergia veitchii: Effects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis

et al. 2022

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Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3.

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Über das Auftreten der sogenannten “Weidekrankheit” bei Kühen in Österreich im Zusammenhang mit Düngung und Fütterung

Cited by 25 publications

References 82 publications

Enzootic calcinosis in sheep in Uruguay: a brief review and report of two outbreaks

Enzootic calcinosis in sheep in Uruguay: a brief review and report of two outbreaks

Zur Kalzinose des Rindes

Poisoning by Nierembergia veitchii: Effects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis

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