Über Adenylsäure im Zentralnervensystem

Chemical Characteristics and Physiological Rôles of Glutamine.

“…Evidence at hand does not warrant a detailed discussion of this point, but suffice it to say in suggestion that (1) cozymase has been shown to be a necessary factor in the transamination of glutamic acid in vitro9, and (2) Bruhl (39) observed that in convulsive states the concentration of ammonia in brain tissue increases as that of adenylic acid decreases. Riebeling (200) states that 75 per cent of the am-* Glutamic acid dehydrogenase of higher plants has been said to act only in presence of coenzyme I, while that of lower plants, such as yeast or B. colt, acts only in the presence of coenzyme II, and that of animal tissues acts in the presence of either coenzyme I or coenzyme II (63). monia which brain tissue can liberate comes from adenylic acid, and Weil-Malherbe (300) drew attention to the unique role played by glutamic acid in brain metabolism.…”