Über „absolute”︁ asymmetrische Synthese.

Concomitant formation of chiral and racemic crystals of a diaryl sulfide

“…6 This phenomenon is known as total spontaneous resolution or crystallisation-induced asymmetric transformation, 8 which may be viewed as a form of absolute asymmetric synthesis. 9,10 Using solid state CD-spectroscopy, 11 it was found that bulk samples of a-1 displayed pronounced circular dichroism (Fig. 2), indicating a significant enantiomeric excess.…”

Isotope Chirality and Asymmetric Autocatalysis: A Possible Entry to Biological Chirality

“…Because of the absence of observable effects, natural abundance isotope chirality is not considered in common chemical thinking. The discovery of asymmetric autocatalysis (Soai 2002;Soai andSato 2001, 2002;Soai et al 1995Soai et al , 2004 and its extremely sensitive variant, which can be used (Caglioti et al 2006a, b;Kawasaki et al 2006a;Vo 2002, 2003;Soai et al 2003) for "absolute enantioselective synthesis" (AES) in the most rigorous sense of the word (Avalos et al 1998;Bredig et al 1923;Feringa and van Delden 1999;Frank 1953;Mislow 2003;Pályi et al 2005) fundamentally changed this picture. It has been shown (Micskei et al 2006a, b;Sato et al 2003), that the AES by the Soai- induction of a very low number of molecules (in the order of e.e.…”

Definition of the term asymmetric synthesis—History and revision

“…In more recent work, using the pure enzyme ( R )‐oxynitrilase in organic solvents, enantiomer ratios of up to >99:1 were achieved; the reaction is even possible on an industrial scale 15 . Another highlight followed in 1912, when Georg Bredig and Paul S. Fiske reported that this reaction could also be catalyzed with the small molecules quinine or quinidine, thus demonstrating the first examples of asymmetric organocatalysis 16 …”