Abstract:To study the effects of ubenimex (UBE) combined with pemetrexed (PEM) on lung adenocarcinoma cell behavior and its molecular mechanism, the tissue samples from lung adenocarcinoma patients who received PEM chemotherapy, those with PEM combined with UBE chemotherapy, and healthy volunteers were retrieved and analyzed. The expression levels of the suppressor of cytokine signaling 1 (SOCS1) in the human lung adenocarcinoma cancer cell lines A549 and PC-9 and tissues were detected by qRT-PCR. MTT assay was perform… Show more
“…Khan et al found that the deficiency of SOCS1 increases susceptibility to hepatocellular carcinoma (HCC), thereby reinforcing cell adaptation to oxidative stress and fostering tumor growth . Chen et al demonstrated that the combination of Ubenimex and Pemetrexed could inhibit the JAK2-STAT3 signaling pathway by upregulating SOCS1 expression, thus impeding the development of cancer cells . The SYVN1 gene encodes E3 ligase synovium protein 1 (SYVN1), which involves the development and metastasis of hepatocellular carcinoma.…”
Section: Resultsmentioning
confidence: 99%
“…54 Chen et al demonstrated that the combination of Ubenimex and Pemetrexed could inhibit the JAK2-STAT3 signaling pathway by upregulating SOCS1 expression, thus impeding the development of cancer cells. 55 The SYVN1 gene encodes E3 ligase synovium protein 1 (SYVN1), which involves the development and metastasis of hepatocellular carcinoma. After knocking down SYVN1, the migration and invasion ability of liver cancer cells were decreased.…”
The exploration of novel anticancer compounds based on
natural
cyclopeptides has emerged as a pivotal paradigm in the contemporary
advancement of macrocyclic pharmaceuticals. Phakellistatin 13 is a cycloheptapeptide derived from the brown snubby sponge and
exhibits remarkable antitumor activity. In this study, we have designed
and synthesized a series of chiral cyclopeptides incorporating the
rigid isoindolinone moiety at various sites within the natural cycloheptapeptide
Phakellistatin 13, with the aim of investigating conformationally
constrained cyclopeptides as potential antitumor agents. Cyclopeptide
3, comprising alternating l-/d-amino acid residues,
exhibited promising antihepatocellular carcinoma effects. Detailed
biological experiments have revealed that Phakellistatin 13 analogs effectively inhibit the proliferation of tumor cells and
induce apoptosis and autophagy, while also causing cell cycle arrest
through the modulation of the p53 and mitogen-activated protein kinase
(MAPK) signaling pathway. This study not only provides valuable insights
into chemical structural modifications but also contributes to a deeper
understanding of the biological mechanisms underlying the development
of natural cyclopeptide-based drugs.
“…Khan et al found that the deficiency of SOCS1 increases susceptibility to hepatocellular carcinoma (HCC), thereby reinforcing cell adaptation to oxidative stress and fostering tumor growth . Chen et al demonstrated that the combination of Ubenimex and Pemetrexed could inhibit the JAK2-STAT3 signaling pathway by upregulating SOCS1 expression, thus impeding the development of cancer cells . The SYVN1 gene encodes E3 ligase synovium protein 1 (SYVN1), which involves the development and metastasis of hepatocellular carcinoma.…”
Section: Resultsmentioning
confidence: 99%
“…54 Chen et al demonstrated that the combination of Ubenimex and Pemetrexed could inhibit the JAK2-STAT3 signaling pathway by upregulating SOCS1 expression, thus impeding the development of cancer cells. 55 The SYVN1 gene encodes E3 ligase synovium protein 1 (SYVN1), which involves the development and metastasis of hepatocellular carcinoma. After knocking down SYVN1, the migration and invasion ability of liver cancer cells were decreased.…”
The exploration of novel anticancer compounds based on
natural
cyclopeptides has emerged as a pivotal paradigm in the contemporary
advancement of macrocyclic pharmaceuticals. Phakellistatin 13 is a cycloheptapeptide derived from the brown snubby sponge and
exhibits remarkable antitumor activity. In this study, we have designed
and synthesized a series of chiral cyclopeptides incorporating the
rigid isoindolinone moiety at various sites within the natural cycloheptapeptide
Phakellistatin 13, with the aim of investigating conformationally
constrained cyclopeptides as potential antitumor agents. Cyclopeptide
3, comprising alternating l-/d-amino acid residues,
exhibited promising antihepatocellular carcinoma effects. Detailed
biological experiments have revealed that Phakellistatin 13 analogs effectively inhibit the proliferation of tumor cells and
induce apoptosis and autophagy, while also causing cell cycle arrest
through the modulation of the p53 and mitogen-activated protein kinase
(MAPK) signaling pathway. This study not only provides valuable insights
into chemical structural modifications but also contributes to a deeper
understanding of the biological mechanisms underlying the development
of natural cyclopeptide-based drugs.
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