Unmanned aerial vehicles (UAVs) operate with large degrees of autonomy when executing tasks from a ground-based controller. However, questions regarding the human-machine intersection remain open. In this work, we design an (immersive) interface for drone management. Our interface supports operators in mission execution of one or several (automated) UAVs within a fleet. This allows operators to assign tasks to UAVs, while safe operations are ensured through in-flight conflict detection and prevention.Our interface fulfills both functional (e.g., reliability) and non-functional requirements (e.g., perceived cognitive load during use). A key design challenge stems from the latency in information exchanges, which introduces information asymmetries between the humans and UAVs. We overcome previous information asymmetries by proposing a set of design principles, whereby we partially relegate the informationprocessing and decision-making capabilities to the UAVs. We then validate the effectiveness of our interface design experimentally, which succeeds in reducing the perceived cognitive load while improving the task performance. Altogether, this work has implications for designing interfaces in human-machine collaboration, so that humans can effectively control, interact, or collaborate with automated machines, such as UAVs.INDEX TERMS unmanned aerial vehicle (UAV), user interfaces, system analysis and design, drone management, in-flight conflict detection and resolution (CDR), field test