U-shaped relationship between vitamin D levels and long-term outcome in large cohort of survivors of acute myocardial infarction

Aleksova, Aneta; Beltrami, Antonio Paolo; Belfiore, Rita; Barbati, Giulia; Nucci, Milena Di; Scapol, Sara; Paris, Valerio De; Carriere, Cosimo; Sinagra, Gianfranco

doi:10.1016/j.ijcard.2016.08.322

Cited by 21 publications

(17 citation statements)

References 38 publications

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“…However, due to various confounding factors, there are discrepancies in studies on the low vitamin D and CVD association. Further, Aleksova et al [27] found a U-shaped curve between levels of vitamin D and myocardial infarction, suggesting the association of both low and high levels of vitamin D and CVD. Therefore, further understanding and research studies are needed.…”

Section: Introductionmentioning

confidence: 99%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

118

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Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.

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Section: Introductionmentioning

confidence: 99%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

118

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“…In a cohort study in 2016, the relationship between 25(OH)D levels and long-term mortality in patients with acute MI was nonlinear and U-shaped. For those who had 25(OH)D level of <10 ng/mL and >30 ng/mL, the estimated hazard rate was 3.02 times higher compared to those with level 20-30 ng/mL [34]. We employed similar categorization which may explain why telomerase prediction of long-term survival mediated by 25(OH)D levels in our study.…”

Section: Discussionmentioning

confidence: 85%

“…We calculated cut-off point with ROC curve. 25(OH)D was categorized into three groups (<20, 20-30, and >30) based on previous reports in literature [25,[33][34][35]. We estimated the survival curves for each group using the Kaplan-Meir method and performed a log-rank test for comparing survival curves of different groups.…”

Section: Discussionmentioning

confidence: 99%

The predictive role of circulating telomerase and vitamin D for long-term survival in patients undergoing coronary artery bypass grafting surgery (CABG)

et al. 2020

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Backgrounds Cardiovascular disease (CVD) is the leading cause of mortality all over the globe. Inflammation is believed to play a pivotal role in the pathophysiology of CVD. While there are studies on the interrelationship of telomerase and vitamin D and their involvement in CVD, their independent contributions to long-term outcomes in patients with CVD are not well-defined. This study aimed to investigate the association of both telomerase and vitamin D concentrations with 10-year survival among candidates of coronary artery bypass grafting (CABG) surgery. Methods Participants were 404 patients from Tehran Heart Center-Coronary Outcome Measurement (THC-COM) cohort who were recruited from CABG surgery candidates in 2006. In addition to demographic and clinical data including risk factors for coronary artery disease, laboratory parameters such as markers of inflammation as well as baseline serum 25-hydroxy vitamin D [25(OH)D] and telomerase concentrations were measured. Cardiac function indexes alongside outcome measures such as mortality and survival days were recorded for every patient up to 10 years after CABG. Cox-proportional hazard model was used to study the association between all-cause mortality and research parameters.

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“…Vitamin D (VitD) deficiency, a worldwide health problem, emerged in the last years as a cardiovascular risk factor, being associated with the development of coronary atherosclerosis [5] and with a worse prognosis of patients surviving MI [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Also, VitD reduces renin-angiotensin-aldosterone system (RAAS) activity through downregulation of renin secretion [12]. Furthermore, hypovitaminosis D (hypovitD) correlates with subsequent adverse cardiac remodeling and mortality [6,13].…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus and Vitamin D Deficiency: Comparable Effect on Survival and a Deadly Association after a Myocardial Infarction

Aleksova

Ferro

Gagno

et al. 2020

JCM

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Survivors after a myocardial infarction (MI), especially those with diabetes mellitus (DM), remain at high risk of further events. Identifying and treating factors that may influence survival may open new therapeutic strategies. We assessed the impact on prognosis of DM and hypovitaminosis D (hypovitD), alone or combined. In this prospective, observational study, 1081 patients were enrolled surviving an MI and divided into four groups according to their diabetic and VitD status. The primary end-point was composite of all-cause mortality, angina/MI and heart failure (HF). Secondary outcomes were mortality, HF and angina/MI. During a follow-up of 26.1 months (IQR 6.6–64.5), 391 subjects experienced the primary end-point. Patients with DM or hypovitD had similar rate of the composite end-point. Patients with only hypovitD or DM did not differ regarding components of composite end-point (angina p = 0.97, HF p = 0.29, mortality p = 0.62). DM and VitD deficiency had similarly adjusted risks for primary end-point (HR 1.3, 95%CI 1.05–1.61; HR 1.3, 95% CI 1.04–1.64). The adjusted HR for primary composite end-point for patients with hypovitD and DM was 1.69 (95%CI 1.25–2.29, p = 0.001) in comparison to patients with neither hypoD nor DM. In conclusion, DM and hypovitD, individually and synergistically, are associated with a worse outcome after MI.

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U-shaped relationship between vitamin D levels and long-term outcome in large cohort of survivors of acute myocardial infarction

Cited by 21 publications

References 38 publications

Role of Vitamin D in Cardiovascular Diseases

Role of Vitamin D in Cardiovascular Diseases

The predictive role of circulating telomerase and vitamin D for long-term survival in patients undergoing coronary artery bypass grafting surgery (CABG)

Diabetes Mellitus and Vitamin D Deficiency: Comparable Effect on Survival and a Deadly Association after a Myocardial Infarction

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