Objective-Although custodial grandchildren are believed to be at greater risk of emotional and behavioral problems than children in general, scant research has examined this important public health issue.Methods-This study involves data from 733 custodial grandmothers participating in a study funded by the National Institute of Mental Health on custodial grandparenting and 9,878 caregivers from the 2001 National Health Interview Survey (NHIS) who completed the Strengths and Difficulties Questionnaire (SDQ) in reference to target children between ages four and 17. These two data sets were used to determine if custodial grandmothers report greater emotional and behavioral difficulties, as measured by the SDQ, for custodial grandchildren than do caregivers of children from the NHIS normative sample.Results-Custodial grandchildren fared worse than children from the NHIS sample across all domains measured by the SDQ subscales, regardless of the child's gender and whether reporters were recruited by population-based or convenience sampling methods. Comparisons within the sample of 733 custodial grandmothers showed that higher levels of difficulties were reported when grandmothers were caring for boys, were recruited by convenience versus population-based sampling, and were white. Comparisons of the banded scores computed for each SDQ subscale suggested that custodial grandchildren have different cutoff points than children in the general population for a likely diagnosis of a psychiatric disorder.Conclusions-Similar to other children in kinship care arrangements, custodial grandchildren are reported by their caregivers to have higher levels of behavioral and emotional disturbances than children in the overall U.S. population.Although increasing numbers of grandparents are becoming surrogate parents to grandchildren (1), little is known about how custodial grandchildren fare in these families. Yet there are two major reasons why custodial grandchildren may encounter greater risk of behavioral and emotional difficulties than children in general. One reason is that custodial grandchildren typically receive care from grandparents because of such predicaments among their parents as substance abuse, child abuse and neglect, teenage pregnancy, death, illness, divorce, incarceration, and HIV-AIDS (2). Such predicaments bear numerous risks of psychopathology among custodial grandchildren, including exposure to prenatal toxins, early childhood trauma,The authors report no competing interests.An earlier version of this article was presented at the annual scientific meeting of the Gerontological Society of America, November 16-20, 2006, Dallas. NIH Public Access Another reason why custodial grandchildren may experience higher risk of emotional and behavioral difficulties concerns the numerous challenges that grandparents face as caregivers. For many this role is developmentally off time, unplanned, ambiguous, and undertaken with considerable ambivalence (5-7). Additional challenges to raising custodial grandchildren in...