Tyrosol Ameliorates the Symptoms of Obesity, Promotes Adipose Thermogenesis, and Modulates the Composition of Gut Microbiota in HFD Fed Mice

Xiao-ping, LI; Wei, Teng; Li, Jingfang; Yuan, Yuan; Wu, Min; Chen, Fang; Deng, Zeyuan; Luo, Ting

doi:10.1002/mnfr.202101015

Cited by 27 publications

(20 citation statements)

References 46 publications

(57 reference statements)

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“…Since PGC-1α is one of the major transcription factors of non-shivering thermogenesis ( 89 ), phytochemicals that potential to activate its co-activator PPARα draws a lot of attention to induce thermogenesis in rodent models. Li et al ( 90 ) reported that tyrosol, one of the main polyphenolic compounds in extra virgin olive oil, acted as a ligand which binds with PPARα, and increased its downstream genes expression, such as uncoupling protein 1, iodothyronine deiodinase 2 and PGC-1α, resulted in reduced body weight gain in HFD-induced obese mice.…”

Section: Peroxisome Proliferator-activated Receptors (Ppars) Regulationmentioning

confidence: 99%

The Structure Basis of Phytochemicals as Metabolic Signals for Combating Obesity

Xiao-ping

Zheng²,

Zhang³

et al. 2022

Front. Nutr.

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The consumption of phytochemicals, bioactive compounds in fruits and vegetables, has been demonstrated to ameliorate obesity and related metabolic symptoms by regulating specific metabolic pathways. This review summarizes the progress made in our understanding of the potential of phytochemicals as metabolic signals: we discuss herein selected molecular mechanisms which are involved in the occurrence of obesity that may be regulated by phytochemicals. The focus of our review highlights the regulation of transcription factors toll like receptor 4 (TLR4), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the peroxisome proliferator-activated receptors (PPARs), fat mass and obesity-associated protein (FTO) and regulation of microRNAs (miRNA). In this review, the effect of phytochemicals on signaling pathways involved in obesity were discussed on the basis of their chemical structure, suggesting molecular mechanisms for how phytochemicals may impact these signaling pathways. For example, compounds with an isothiocyanate group or an α, β-unsaturated carbonyl group may interact with the TLR4 signaling pathway. Regarding Nrf2, we examine compounds possessing an α, β-unsaturated carbonyl group which binds covalently with the cysteine thiols of Keap1. Additionally, phytochemical activation of PPARs, FTO and miRNAs were summarized. This information may be of value to better understand how specific phytochemicals interact with specific signaling pathways and help guide the development of new drugs to combat obesity and related metabolic diseases.

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Section: Peroxisome Proliferator-activated Receptors (Ppars) Regulationmentioning

confidence: 99%

The Structure Basis of Phytochemicals as Metabolic Signals for Combating Obesity

Xiao-ping

Zheng²,

Zhang³

et al. 2022

Front. Nutr.

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“…Compared with PN group, taking SePN increased the relative abundance of Muribaculaceae, Rikenellaceae, Erysipelotrichaceae (Supplementary Figure S1). At present, studies showed that the increase in the abundance of these microorganisms is negatively correlated with the risk of disease induced by HFD (49)(50)(51)(52). Interestingly, some studies showed that dietary selenium supplementation can improve their relative abundance (53, 54).…”

Section: Discussionmentioning

confidence: 99%

Feeding foliar nano-selenium biofortified panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets

Dong

Yan

et al. 2022

Front. Nutr.

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Nano-selenium (nano-Se) has been extensively explored as a biostimulant for improving the quality of grain crops. However, there are few reports about the effect on the medicinal components of Chinese herbal medicine cultured with nano-Se. Here, we sprayed nano-Se during the cultivation of Panax notoginseng (SePN), and measured the changes of medicinal components compared with conventional Panax notoginseng (PN). Furthermore, we identified a more pronounced effect of SePN on reducing obesity in animals compared with PN. By measuring antioxidant capacity, histopathology, gene expression related to glycolipid metabolism, and gut microbiota composition, we propose a potential mechanism for SePN to improve animal health. Compared with the control groups, foliar spraying of nano-Se increased saponins contents (Rb2, Rb3, Rc, F2, Rb2, and Rf) in the roots of Panax notoginseng, the content of Rb2 increased by 3.9 times particularly. Interestingly, animal studies indicated that taking selenium-rich Panax notoginseng (SePN) can further ameliorate liver antioxidation (SOD, MDA, and GSH) and enzyme activities involved in glycolipid metabolism (ATGL and PFK). It also relieved inflammation and regulated the expression of genes (MCAD, PPAR-α, and PCSK9) related to fatty acid oxidation. The abundance ratio of Firmicutes/Bacteroides and beneficial bacteria abundance (Bifidobacterium, Butyricimonas, and Parasutterella) in gut microbiota were improved relative to the control. In summary, the application of nano-Se on PN may effectively raise the content of Panax notoginseng saponins (PNS) and immensely lower the risk of metabolic disorders of glycolipids.

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“…However, intestinal-related diseases, such as diarrhea, colitis, and colorectal cancer, have been demonstrated to perturb intestinal homeostasis, resulting in dysbiosis (35,36). Moreover, recent studies have also shown that diabetes, high blood pressure, and obesity could also cause significant changes in the gut microbiota (37)(38)(39). In this study, we selected feces to explore the gut microbial changes in buffalos with mastitis in consideration of the samples' availability and subjects' particularity.…”

Section: Discussionmentioning

confidence: 99%

Integrated Bacteria-Fungi Diversity Analysis Reveals the Gut Microbial Changes in Buffalo With Mastitis

Chen

Zhang

et al. 2022

Front. Vet. Sci.

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The gut microbial community is closely related to mastitis, but studies regarding the influences of mastitis on gut microbiota in buffalo remain scarce. Herein, we characterized the differences in gut bacterial and fungal communities between mastitis-affected and healthy buffalos. Interestingly, although mastitis had no effect on gut bacterial and fungal diversities in the buffalos, some bacterial and fungal taxa were significantly altered. Bacterial and fungal taxonomic analysis showed that the preponderant bacterial phyla (Firmicutes and Bacteroidetes) and fungal phyla (Ascomycota and Basidiomycota) in buffalo were the same regardless of health status. At the level of genus, the changes in some gut bacterial and fungal abundances between both groups were gradually observed. Compared with healthy buffalos, the proportions of 3 bacterial genera (uncultured_bacterium_f_Muribaculaceae, Eubacterium_nodatum_group, and Lachnoclostridium_10) and 1 fungal genus (Pichia) in the mastitis-affected buffalo were significantly increased, whereas 4 bacterial genera (Ruminococcus_2, Candidatus_Stoquefichus, Turicibacter, and Cellulosilyticum) and 4 fungal genera (Cladosporium, Thermothelomyces, Ganoderma and Aspergillus) were significantly decreased. Taken together, this research revealed that there was significant difference in the compositions of the gut microbial community between the healthy and mastitis-affected buffalos. To our knowledge, this is the first insight into the characteristics of the gut microbiota in buffalos with mastitis, which is beneficial to understand the gut microbial information of buffalo in different health states and elucidate the pathogenesis of mastitis from the gut microbial perspective.

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Tyrosol Ameliorates the Symptoms of Obesity, Promotes Adipose Thermogenesis, and Modulates the Composition of Gut Microbiota in HFD Fed Mice

Cited by 27 publications

References 46 publications

The Structure Basis of Phytochemicals as Metabolic Signals for Combating Obesity

The Structure Basis of Phytochemicals as Metabolic Signals for Combating Obesity

Feeding foliar nano-selenium biofortified panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets

Integrated Bacteria-Fungi Diversity Analysis Reveals the Gut Microbial Changes in Buffalo With Mastitis

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