Tyrosine Sulfation Modulates the Binding Affinity of Chemokine-Targeting Nanobodies
Joshua J. Dilly,
Alexandra L. Morgan,
Max J. Bedding
et al.
Abstract:Chemokines are an important family of small proteins integral to leukocyte recruitment during inflammation. Dysregulation of the chemokine−chemokine receptor axis is implicated in many diseases, and both chemokines and their cognate receptors have been the targets of therapeutic development. Analysis of the antigen-binding regions of chemokine-binding nanobodies revealed a sequence motif suggestive of tyrosine sulfation. Given the well-established importance of post-translational tyrosine sulfation of receptor… Show more
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