Tyrosine platelet levels in normal subjects

D’Andrea, Giovanni; Cananzi, A.R.; Morra, M; Fornasiero, S.; Ferro-Milone, F; Joseph, Rajiv; Grunfeld, Saul; Welch, K. M. A.

doi:10.1016/0049-3848(89)90118-7

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…The preparation was then centrifuged for 5 min at 1200 g and an aliquot of supernatant was injected into a Millipore Waters HPLC system connected to a Perkin Elmer fluorescence spectrometer. The amino acids were analysed according to a modification of previously described methods (11)(12)(13). The wavelengths used to detect the amino acids were 330 nm for the excitation and 445 nm for the emission respectively.…”

Section: Methodsmentioning

confidence: 99%

Platelet Glycine, Glutamate and Aspartate in Primary Headache

et al. 1991

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Platelet levels of glutamic and aspartic acid and glycine were measured in patients with migraine with aura, migraine without aura, tension headache and cluster headache. High levels of these amino acids were found in patients with migraine with aura compared to normal subjects and other headache groups. During headache, glutamate levels further increased in migraine with aura patients. These findings may have relevance to the neurological symptoms of migraine with aura.

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Section: Methodsmentioning

confidence: 99%

Platelet Glycine, Glutamate and Aspartate in Primary Headache

et al. 1991

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“…The aminoacids were analysed according to a modification of previously described methods (11)(12)(13). We added 50 ml of sample to a solution containing 400 ml of boric acid, 490 ml of methanol, 50 ml of opthalaldehyde (OPA) and 10 ml of internal standard norvaline (C 5 H 11 NO 2 ).…”

Section: Determination Of Glutamate and Glutaminementioning

confidence: 99%

Platelet and Plasma Levels of Glutamate and Glutamine in Migraine With and Without Aura

Cananzi¹,

D’Andrea

Perini

et al. 1995

Cephalalgia

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We evaluated plasma and platelet glutamate and glutamine levels in migraine with and without aura during headache-free periods and compared the results with those of normal controls. The plasma and platelet levels of glutamine in migraine with and without aura were normal. Migraine without aura patients had higher glutamate levels in plasma, and normal platelet levels. In migraine with aura patients, glutamate levels were high in platelets, but not in plasma. This suggests different profiles of excitatory amino acid metabolism in migraine with and without aura.

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Decreased Collagen-Induced Platelet Aggregation and Increased Platelet Arginine Levels in Migraine: A Possible Link With The NO Pathway

D’Andrea¹,

Cananzi²,

Perini³

et al. 1994

Cephalalgia

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We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis.

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Tyrosine platelet levels in normal subjects

Cited by 3 publications

References 8 publications

Platelet Glycine, Glutamate and Aspartate in Primary Headache

Platelet Glycine, Glutamate and Aspartate in Primary Headache

Platelet and Plasma Levels of Glutamate and Glutamine in Migraine With and Without Aura

Decreased Collagen-Induced Platelet Aggregation and Increased Platelet Arginine Levels in Migraine: A Possible Link With The NO Pathway

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