1989
DOI: 10.1016/0006-291x(89)90841-3
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Tyrosine phosphorylation in human neutrophil

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Cited by 123 publications
(53 citation statements)
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“…While much is known about the coupling of G proteins to phospholipase C, the initial steps involved in the initiation of the tyrosine phosphorylation cascade(s) upon engagement of GPCRs remain, for the most part, undetermined. This lack of knowledge contrasts with the documented importance of tyrosine phosphorylation events in the initiation and/or regulation of several neutrophil functions established using correlative, pharmacological (7)(8)(9)(10)(11), and genetic approaches (12)(13)(14)(15) .…”
mentioning
confidence: 94%
“…While much is known about the coupling of G proteins to phospholipase C, the initial steps involved in the initiation of the tyrosine phosphorylation cascade(s) upon engagement of GPCRs remain, for the most part, undetermined. This lack of knowledge contrasts with the documented importance of tyrosine phosphorylation events in the initiation and/or regulation of several neutrophil functions established using correlative, pharmacological (7)(8)(9)(10)(11), and genetic approaches (12)(13)(14)(15) .…”
mentioning
confidence: 94%
“…Amplified products of P2X [1][2][3][4][5][6][7] were observed in appropriate amounts when homogenized rat brain was used as the positive control for RT-PCR (Fig. 7: A, B).…”
Section: Identification Of Purinoceptor Mrna In Rat Neutrophils By Rtmentioning
confidence: 96%
“…A bacterial peptide, N-formyl-methionyl-leucylphenylalanine (fMLP), identified as a potent leukocyte chemoattractant, binds to receptors on the neutrophil outer membrane, thereby activating these cells through a G-protein-coupled pathway (6,7). ATP and adenosine modulate neutrophil functions, including chemotaxis (8,9).…”
Section: Introductionmentioning
confidence: 99%
“…The GTP-Ga and the free Gbg subunit interact with their respective effector proteins that further amplify the signal. GPCR activation triggers rapid protein tyrosine phosphorylation in neutrophils (8,9), and treatment with inhibitors of tyrosine kinases blocks neutrophil responses to chemoattractants (10,11). Among cytosolic tyrosine kinases, members of the Src family have been implicated in fMLF-mediated signal transduction (12)(13)(14).…”
mentioning
confidence: 99%